关键的牙周病原体可能会调解牙周炎和克罗恩病之间的潜在病原性关系
Boyang Sun1, Ying Wang1, Mengmeng Wu2
1Department of General Dentistry, Research institute of Stomatology, Nanjing stomatological Hospital, Affiliated hospital of medical school, Nanjing University, Nanjing, 210008, China.
BMC oral health
|June 7, 2024
概括
牙周病原体如 Porphyromonas gingivalis 和 Fusobacterium nucleatum 可能会导致克罗恩氏病 (CD) 的进展. 这些细菌可以进入肠道,恶化结肠炎,增加肠道的透性,这表明牙周炎和CD之间存在联系.
科学领域:
- 微生物学 微生物学
- 胃肠病学 胃肠病学
- 牙周病学 牙周病学
背景情况:
- 牙周炎经常在克罗恩病 (CD) 患者中观察到.
- 口腔病原体在牙周炎和牙周病共同发生中的特定作用尚不清楚.
研究的目的:
- 调查牙周病原体在关联牙周炎和CD的潜在作用.
- 探索特定牙周病原体对肠道炎症和肠道屏障功能的影响.
主要方法:
- 来自健康个体,CD患者,牙周炎患者和患有这两种疾病的患者的唾液样本使用16S rRNA测序进行了分析.
- 动物模型被用来评估Porphyromonas gingivalis和Fusobacterium nucleatum对大肠炎和全身炎症的影响.
- 实验室Caco-2细胞模型被用来检查这些病原体对肠道上皮质屏障完整性的影响.
主要成果:
- 患有牙周炎和CD同时存在的患者显示Fusobacterium,Actinomyces,Leptotrichia和Prevotella的水平升高,与牙周炎的严重程度相关.
- 链球菌,尼塞里亚菌,血球菌和双胞胎菌的水平降低,与牙周炎的严重程度有负相关.
- 向小鼠施用P. gingivalis和F. nucleatum加速了CD的进展,加重了结肠炎,并诱导了全身炎症. 这些病原体破坏了肠道上皮质的紧密结节,增加了肠道的透性.
结论:
- 牙周病原体与共存的牙周炎和克罗恩病的病原发生有关.
- 这些发现提供了关于口腔健康和炎症性肠道疾病之间的联系的见解.
- 这项研究提出了潜在的治疗目标,用于管理共存的牙周炎和CD.
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