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失眠和膀癌之间没有因果关系:双向的双样本孟德尔随机化研究

Lihuan Du¹, Bohan Wang², Jiaming Wen²

¹Department of Urology, The Second Affiliated Hospital of Zhejiang University, No. 88 Jiefang Road, Hangzhou, 310009, China. dlh1984@zju.edu.cn.

European journal of medical research

|June 7, 2024

概括

这项研究发现失眠和膀癌之间没有因果关系. 门德尔随机化分析证实,这两种情况似乎都不会引起对方,支持目前的证据.

科学领域:

遗传学遗传学是一个
流行病学流行病学
在瘤学瘤学.

背景情况:

观察性研究表明,失眠和膀癌之间可能存在联系.
失眠和膀癌之间的因果关系尚不清楚.

研究的目的:

通过双向双样本孟德尔随机化分析,研究失眠和膀癌之间的潜在因果关系.

主要方法:

利用了针对失眠和膀癌的全基因组关联研究 (GWAS) 的总结数据.
采用了各种孟德尔随机化方法,包括逆方差加权 (IVW) 和加权中位数.
评估了型和异质性,并进行了灵敏度分析.

主要成果:

没有发现失眠对膀癌风险的显著因果关系 (IVW OR=0.761,P=0.76).
没有发现膀癌对失眠风险的显著因果关系 (IVW OR=1.47,P=0.24).
敏感性分析和异质性/多重性测试支持了这些发现.

结论:

这项门德尔随机化研究没有发现证据支持失眠和膀癌之间的因果关系.

关键词:

膀癌是一种癌症.原因关系是因果关系.失眠是一种失眠.门德尔的随机化风险因素风险因素风险因素

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