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在患有抑郁症和没有抑郁症的早泄患者之间,功能性大脑网络中的条纹-thalamo-皮质电路的拓差异

Xinyue Zhang¹, Peining Niu², Mengqing Su³

¹School of Medicine & Holistic Integrative Medicine, Nanjing University of Chinese Medicine, Nanjing, China.

Brain and behavior

|June 8, 2024

概括

这项研究揭示了抑郁症过早射精 (PE) 患者的大脑网络连接的改变,显示功能整合的增加和减少. 这些发现为PE和并发性抑郁症的神经基础提供了新的见解.

科学领域:

神经科学是一个神经科学.
精神病学是一个精神病学.
医疗成像医学成像

背景情况:

提前射精 (PE) 是一种常见的男性性功能障碍,通常与抑郁症等心理因素有关.
神经成像研究表明PE患者的结构和功能大脑异常,但PE-抑郁症并发症的神经证据有限.

研究的目的:

通过神经成像来研究伴随性抑郁症PE患者功能性大脑网络的拓变化.
探索PE的神经基础及其与抑郁症的同时发生.

主要方法:

休息状态功能磁共振成像 (rs-fMRI) 数据从60名PE患者 (30名患有抑郁症,30名没有) 和29名健康对照患者中收集.
图形理论分析被用来构建功能性大脑网络,并计算中心性和效率等节点参数.
对多次比较的结果进行了校正,使用家庭智能错误 (FWE) 校正 (p < .05).

主要成果:

与对照人群相比,患有抑郁症的PE患者表现出右皮中增加的中心度和总效率,以及右丘脑中增加的中心度.
没有抑郁症的PE患者表现出右和丘脑的中心度增加,以及右,丘脑和丘脑的整体效率增加,与对照组相比.
与没有抑郁症的PE患者相比,患有抑郁症的患者表现出右和lamus的中心度降低,以及右前,和lamus的整体效率降低.

结论:

大脑中功能连接和信息整合的改变可能与PE和并发性抑郁症有关.
这些发现为EP和抑郁症共患的病理机制提供了新的见解.

关键词:

大脑网络大脑网络抑郁抑郁症抑郁症抑郁症是一种图形理论分析图形理论分析过早射精过早射精静止状态功能磁共振成像技术

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