扩大的周血管空间与多发性硬化症中的大脑微血管病变和衰老有关
Serena Borrelli1, François Guisset2, Colin Vanden Bulcke3
1Neuroinflammation Imaging Lab (NIL), Institute of NeuroScience, Université catholique de Louvain, Brussels, Belgium/Department of Neurology, Hôpital Erasme, Hôpital Universitaire de Bruxelles, Université Libre de Brussels, Brussels, Belgium.
Multiple sclerosis (Houndmills, Basingstoke, England)
|June 8, 2024
概括
多发性硬化症 (MS) 中扩大周周血管空间 (EPVS) 与微血管病有关,而不是神经炎症. 高EPVS与加速的神经退行和大脑衰老相关,这表明在MS进展中发挥了作用.
科学领域:
- 神经成像是一种神经成像.
- 神经学 神经学
- 放射学 放射学是一门学科.
背景情况:
- 越来越多的证据将脑MRI上的扩大周血管空间 (EPVS) 与多发性硬化症 (MS) 联系在一起.
- 对于EPVS在MS发病过程中的具体作用尚不清楚.
- 这项研究研究了EPVS和关键MS特征之间的关联.
研究的目的:
- 为了检查EPVS和神经炎症/神经退行性标志物之间的横截面关系,在一个大型的,多中心的MS队列.
- 为了确定在MS患者中高EPVS负担的预测因素.
主要方法:
- 207名多发性硬化患者接受了EPVS评估的3T脑部MRI,分为高 (>=2) 和低 (<2) 类别.
- 核磁共振成像生物标志物包括大脑预测的年龄差异 (大脑-PAD),中央静脉标志 (CVS%),病变负载,大脑体积和皮质病变.
- 使用随机森林分类方法来确定变量在预测EPVS类别中的相对重要性.
主要成果:
- 患有高EPVS的患者年龄较大,有更多的血管风险因素,CVS率较低,大脑体积减少,大脑预测年龄较大.
- 在调整了年龄和血管风险因素后,高EPVS与较低的CVS%,减少的大脑体积和较高的大脑PAD相关.
- 随机森林分析发现大脑PAD是高EPVS的最重要的预测因素.
结论:
- 在MS中EPVS可能代表微血管病,而不是神经炎症.
- 在多发性硬化症中,EPVS可能有助于加速神经退行.
- 大脑PAD是MS中高EPVS负担的关键预测因素.
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