禁食胰腺多可预测2型糖尿病的微血管和宏血管并发症:一项观察性研究
Amir H Sam1, Adam J Buckley2, Brian Y H Lam3
1Division of Diabetes, Endocrinology and Metabolism, Section of Endocrinology and Investigative Medicine, Imperial College London, London, UK.
Diabetes/metabolism research and reviews
|June 8, 2024
概括
胰腺多 (PP) 的升高与糖尿病并发症,如视网膜病变和心血管疾病有关. 这表明PP可能在糖尿病病理生理学和风险评估中发挥作用.
科学领域:
- 内分泌学 在内分泌学.
- 代谢疾病 代谢疾病
- 眼科医生 眼科 眼科
背景情况:
- 胰腺多 (PP) 水平通常在患有血管风险因素的个体中升高,包括2型糖尿病和内脏脂肪增加.
- 了解PP和糖尿病并发症之间的关系对于风险分层和管理至关重要.
研究的目的:
- 调查胰腺多 (PP) 与糖尿病中微血管和宏血管并发症之间的潜在关联.
- 探索PP可能影响糖尿病并发症的机制性途径.
主要方法:
- 一项动物研究涉及皮下PP输液在高脂肪饮食小鼠模型,与视网膜mRNA分析.
- 一项人类研究测量了1478名参与者的禁食PP,随后记录了血管并发症的中位数为5.5年.
主要成果:
- 在小鼠中,PP输液改变了视网膜基因表达,表明细胞应激和损伤,与糖尿病视网膜病变途径和敏感性基因,毛囊素的上调相一致.
- 在患有2型糖尿病的人群中,高的禁食PP独立与视网膜病变,白色素尿和大血管疾病有关.
- 在非糖尿病患者中,PP还预测了糖尿病的进展.
结论:
- 高速禁食PP是糖尿病血管并发症的独立风险因素,包括视网膜病变和心血管疾病.
- PP似乎影响视网膜通路,可能影响神经元的存活率,并导致糖尿病视网膜病变.
- 这些发现表明PP-fold在糖尿病并发症的发展中具有新的作用,并有可能改善血管风险分层.
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