在COVID-19相关的低血中,认知缺陷和皮质体积损失
Haşim Gezegen1, Ulaş Ay2,3, Bedia Samancı1
1Behavioral Neurology and Movement Disorders Unit, Department of Neurology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
European journal of neurology
|June 8, 2024
概括
患有嗅觉丧失 (缺血症) 的COVID-19幸存者表现出大脑变化,包括嗅球缩和认知功能下降. 这些发现表明,感染后对大脑结构和认知产生长期影响.
科学领域:
- 神经科学是一个神经科学.
- 神经学 神经学
- 眼科医生 眼科 眼科
背景情况:
- 在COVID-19患者中,多达73%的人报告低血 (嗅觉丧失).
- 无论是外围还是中央,COVID-19诱导的低血的神经基础仍然不清楚.
- 了解这些影响对于管理COVID-19的长期后果至关重要.
研究的目的:
- 为了研究COVID-19诱导的低血对大脑结构的影响.
- 评估COVID-19相关的嗅觉功能障碍对认知功能的影响.
- 在康复的COVID-19患者中关联嗅觉球体体积和认知表现.
主要方法:
- 招募的参与者:36名COVID-19 (h-COV),21名COVID-19 (n-COV) 和25名健康对照 (HC).
- 使用神经学检查,神经精神病学评估和嗅觉功能的Sniffin' Sticks测试.
- 获得了高分辨率的解剖MRI扫描,以测量嗅球 (OB) 体积和皮质厚度.
主要成果:
- 与对照组相比,体COVID-19患者的认知得分 (Addenbrooke's Cognitive Examination-Revised) 和嗅觉表现明显较低.
- 在h-COV组中观察到左侧和右侧嗅觉球体体积减少.
- 观察到左侧轨道前皮层的缩以及嗅觉得分与大脑结构之间的相关性.
结论:
- 由于COVID-19引起的缺血症与嗅觉球体和与嗅觉相关的皮质结构缩有关.
- 微妙的长期认知缺陷可能是COVID-19后暂时或永久的嗅觉丧失造成的.
- 这些发现凸显了中枢神经系统对SARS-CoV-2感染的脆弱性.
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