系统性红斑狼的恶性:与92名患者的疾病特征的关系 - - 一个单一中心的回顾性研究
Joanna Kosałka-Węgiel1,2, Renata Pacholczak-Madej3,4,5, Radosław Dziedzic6
1Department of Rheumatology and Immunology, Jagiellonian University Medical College, Jakubowskiego 2, Kraków, 30-688, Poland. joanna.kosalka@uj.edu.pl.
Rheumatology international
|June 8, 2024
概括
恶性瘤发生在近10%的系统性红斑狼 (SLE) 患者中,经常出现严重的症状和并发症. 增加瘤警对于改善这些高风险SLE患者的治疗结果至关重要.
科学领域:
- 类风湿病学 类风湿病学
- 在瘤学瘤学.
- 内部医学 内部医学
背景情况:
- 系统性红斑狼 (SLE) 是一种慢性自身免疫性疾病,具有不同的临床表现.
- 患有SLE的患者面临患上瘤疾病的风险增加.
- 了解SLE和恶性瘤之间的相互作用对于患者管理至关重要.
研究的目的:
- 综合评估SLE患有和没有恶性瘤的患者的临床和实验室特征.
- 为了确定与SLE人口中恶性瘤相关的因素.
- 为了告知临床警,并改善SLE癌症患者的治疗结果.
主要方法:
- 在2012年至2022年期间接受治疗的932名成年高加索SLE患者的回顾性分析.
- 收集人口,临床,实验室和治疗数据.
- 患有恶性瘤和没有恶性瘤的SLE患者之间的特征比较.
主要成果:
- 在9.87%的SLE患者中记录了恶性病变,主要是非血液病.
- 患有恶性瘤的SLE患者在发病时年龄较大,疾病持续时间较长,并且更频繁地出现体重减轻,疲劳,发烧,肺和肺部参与以及贫血.
- 在恶性瘤组中观察到心血管疾病,糖尿病,甲状腺功能低下,高血压和高胆固醇血症等并发症的患病率增加.
- 在接受更激烈的免疫抑制治疗时,死亡率在各组之间相似,感染和SLE恶化是导致死亡的主要原因.
结论:
- 恶性瘤在SLE患者中相对较为常见.
- 必须保持瘤学警,特别是在患有严重疾病和并发症的SLE患者中.
- 需要早期检测和管理策略,以改善SLE患有恶性瘤的患者的长期结果.
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