年龄加剧了抑郁症对种族和民族少数群体执行职能的负面影响
Zhimei Niu1, Andreana P Haley2, Alexandra L Clark2
1Department of Psychology, University of Texas at Austin, 108 Dean Keeton Street, Austin, TX, 78712, USA. zhimei.niu@austin.utexas.edu.
Brain imaging and behavior
|June 8, 2024
概括
中年人,特别是西班牙裔和黑人成年人,经历了"双重危险",年龄和抑郁症显著损害了执行职能. 这种认知衰退与这些群体前额叶皮层体积的减少有关.
科学领域:
- 神经科学是一个神经科学.
- 老年学是指老年学的学科.
- 精神病学是一个精神病学.
背景情况:
- 老龄化和抑郁症对认知障碍,特别是执行功能构成风险.
- 有限的研究存在于中年成年人和认知结果的种族种族差异.
- 历史上少数群体可能面临更严重的认知后果.
研究的目的:
- 调查年龄对中年成人抑郁症相关认知障碍的影响.
- 为了检查跨种族群体的潜在大脑体积差异.
- 探索年龄,抑郁症和执行功能之间的相互作用.
主要方法:
- 试点研究涉及176名中年成人:116名非西班牙裔白人和60名西班牙裔和黑人成年人.
- 评估认知功能,专注于执行功能.
- 测量了前额叶皮层体积和抑郁水平.
主要成果:
- 在中年西班牙裔和黑人成年人中,在执行功能方面发现了年龄和抑郁症之间的显著相互作用.
- 非西班牙裔白人成年人没有显示这种相互作用.
- 在西班牙裔和黑人成年人中,前额叶皮层体积减少部分介导了抑郁症和执行功能之间的联系.
结论:
- 抑郁症对执行功能和前额叶皮层完整性的负面影响随着年龄的增长而加剧.
- 从历史上看,少数群体中的个人可能更容易受到这种影响.
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