对复发性鼻癌的新T分期建议
Mingjing Zhu1, Pian Li1,2, Huisi Zhang1
1Department of Radiation Oncology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, 530021, China.
Journal of cancer research and clinical oncology
|June 8, 2024
概括
与当前的UICC/AJCC rT分期相比,复发性鼻癌 (rNPC) 的新分期系统显示了更好的生存预测. 这种新的RT分期旨在更好地指导rNPC患者的治疗决策.
科学领域:
- 在瘤学瘤学.
- 癌症的分期 癌症的分期
- 鼻癌研究 鼻癌研究
背景情况:
- 目前的国际癌症控制联盟/美国癌症联合委员会 (UICC/AJCC) 的RT分期缺乏对复发性鼻癌 (rNPC) 的临床实用性.
- 有效的分期对于指导治疗策略和预测rNPC患者的结果至关重要.
研究的目的:
- 开发和验证一种针对复发性鼻癌 (rNPC) 的新型RT分期系统.
- 为了比较新的rT分期系统与现有的第8版UICC/AJCCrT分期对rNPC患者存活率的预测值.
主要方法:
- 在2012年1月至2020年12月期间诊断出rNPC的175名患者的回顾性分析.
- 采用接收器操作特征 (ROC) 曲线分析来评估分阶段系统的有效性.
- 评估与不同RT阶段相关的总生存 (OS) 和无进展生存 (PFS).
主要成果:
- 第8版UICC/AJCC rT分期显示,在rT1和rT2复发性鼻癌 (rNPC) 患者之间,在OS (p=0.8059) 或PFS (p=0.4045) 中没有显著差异.
- 新提出的RT分期显示,RT1与RT2rNPC患者的OS (p=0.0229) 和PFS (p=0.0459) 有显著差异.
- 在rNPC患者中,OS和PFS的独立预后因素包括吸烟,家族病史和最初复发的时间间隔.
结论:
- 与第八版UICC/AJCC rT分期相比,新开发的rT分期系统为复发性鼻癌 (rNPC) 患者的生存提供了更好的预测价值.
- 拟议的RT分期系统可以作为指导临床治疗决策在rNPC管理中的更有效的工具.
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