多囊卵巢综合征不同表型中的甲状腺自身免疫:单中心体验
E Benelli1, M Marradi1, E Sciarroni1
1Department of Clinical and Experimental Medicine, Section of Endocrinology, University Hospital of Pisa, Via Paradisa 2, 56124, Pisa, Pisa, Italy.
Journal of endocrinological investigation
|June 8, 2024
概括
多囊卵巢综合征 (PCOS) 患者的表型A和B显示出更高的抗甲状腺抗体 (TAb) 频率,包括高位抗甲状腺蛋白和抗甲状腺氧化酶抗体. 甲状腺功能低下症与TAb阳性有关,而不是特定的PCOS表型.
科学领域:
- 内分泌学 在内分泌学.
- 生殖医学 生殖医学
- 免疫学 免疫学 免疫学
背景情况:
- 多囊卵巢综合征 (PCOS) 与哈希莫托的甲状腺炎 (HT) 有关.
- 已经确定了四种不同的PCOS表型.
- 了解PCOS表型与甲状腺自身免疫之间的关系至关重要.
研究的目的:
- 确定四种PCOS表型中抗甲状腺抗体 (TAb) 的流行率.
- 为了评估不同PCOS表型的甲状腺功能.
- 调查PCOS表型与甲状腺自身免疫之间的潜在关联.
主要方法:
- 该研究包括448名被诊断患有PCOS的患者.
- 患者被分为四种表型 (A,B,C,D).
- 分析了TAb的患病率,包括抗thyroglobulin (TgAb) 和抗thyroperoxidase (TPOAb),以及甲状腺功能.
主要成果:
- 总的来说,TAB阳性是20.1%.
- 与表型C和D (10.1%) 相比,A和B表型组合显示出明显更高的TAb阳性 (21.9%).
- 在表型A-B (10.3%) 中,高滴度TgAb的频率明显高于C-D (0%). 甲状腺功能低下与TAB阳性相关 (OR 4.19).
结论:
- 患有PCOS表型A和B的女性表现出TAb的更高频率,包括高位数TgAb和TPOAb.
- 这种增加的自身免疫力可能与这些表型中的荷尔蒙失衡 (雌激素-孕) 有关.
- 在PCOS患者中,TAb阳性是甲状腺功能低下的重要危险因素,独立于表型.
相关概念视频
Autoimmune Disorders
417
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
Concept and Mechanism of Autoimmune Diseases
The immune...
417
Oogenesis
63.7K
In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
63.7K
Gastritis-II: Pathophysiology
316
Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
316
Synthesis and Regulation of Thyroid Hormones
4.5K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
4.5K
Pleiotropy
40.4K
Pleiotropy is the phenomenon in which a single gene impacts multiple, seemingly unrelated phenotypic traits. For example, defects in the SOX10 gene cause Waardenburg Syndrome Type 4, or WS4, which can cause defects in pigmentation, hearing impairments, and an absence of intestinal contractions necessary for elimination. This diversity of phenotypes results from the expression pattern of SOX10 in early embryonic and fetal development. SOX10 is found in neural crest cells that form melanocytes,...
40.4K
Adrenal Gland Disorders
1.5K
Adrenal gland disorders manifest when the production of adrenal hormones deviates from the norm, resulting in either excessive or insufficient concentrations.
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...
1.5K


