治疗抑郁症的psilocybin辅助心理治疗中的协议和实践:系统性审查
Noah Chisamore1, Danica Johnson2, Margery J Q Chen3
1Mood Disorders Psychopharmacology Unit, University Health Network, Toronto, Ontario, Canada; Department of Pharmacology, University of Toronto, Toronto, ON, Canada.
Journal of psychiatric research
|June 8, 2024
概括
松素辅助心理治疗 (PAP) 对抑郁症有希望,但缺乏标准化的方案. 目前的试验在治疗方法上有很大差异,需要更明确的安全和有效使用指南.
科学领域:
- 精神病学是一个精神病学.
- 心理学 心理学 心理学
- 药理学 药理学是指药理学的学科.
背景情况:
- 松素辅助心理治疗 (PAP) 是一种新兴的抑郁症治疗方法.
- 随机对照试验 (RCT) 表明PAP是安全有效的.
- 现有的PAP治疗方案显示出相当大的不一致性.
研究的目的:
- 总结和比较目前用于抑郁症PAP的心理治疗方法.
- 通过审查临床试验协议,为未来的PAP实践提供见解.
主要方法:
- 在Embase,MEDLINE,PsycINFO和CINAHL数据库中进行系统的文献搜索.
- 两个独立的审稿人对心理治疗方案的数据进行了选和分析.
- 包括28篇文章详细介绍了1869篇文章的初步选后的PAP协议.
主要成果:
- 所有审查的PAP协议都包括准备,剂量和整合会议与监测.
- 在会话持续时间,数量和治疗模型中发现了显著的变化和不一致性.
- 许多协议在描述治疗方法时缺乏明确性,阻碍了可复制性.
结论:
- 发表的PAP协议始终包括准备,剂量和整合阶段.
- 目前,由于异质性和缺乏清晰度,没有经过验证的,普遍同意的PAP协议.
- 未来的研究必须明确定义和报告PAP心理治疗成分,以优化疗效和安全.
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