相关实验视频
Updated: Jun 24, 2025

08:38
Extraction and Analysis of Cortisol from Human and Monkey Hair
Published on: January 24, 2014
28.3K
头发皮质醇度在怀孕前和怀孕期间的表征
Diana L Juvinao-Quintero1, Richard G Künzel2, Gloria Larrabure-Torrealva3
1Harvard T.H. Chan School of Public Health, Department of Epidemiology, 677 Huntington Avenue, Kresge 500, Boston, MA 02115, USA.
Psychoneuroendocrinology
|June 8, 2024
概括
在秘鲁队伍中,头发皮质醇度 (HCC) 在怀孕期间增加. 偏见BMI,食物获取,教育,染发和婴儿性别影响HCC,支持其作为母亲和儿童健康的生物标志物的使用.
科学领域:
- 内分泌学 在内分泌学.
- 生殖健康 生殖健康
- 生物标志物开发 生物标志物开发
背景情况:
- 脑下垂体上腺 (HPA) 轴调节压力和怀孕.
- 头发皮质醇度 (HCC) 是HPA轴活动的关键生物标志物.
- 了解产前HCC因素对于母亲和儿童的福祉至关重要,特别是在低收入和中等收入国家 (LMICs).
研究的目的:
- 为了描述预孕和怀孕的特征,HCC.
- 调查与社会人口统计学,怀孕和与头发相关的因素的关联.
主要方法:
- 分析了来自秘鲁2581名孕妇的6厘米头皮头发样本,跨越了四个产前时期.
- 使用LC-MS/MS.进行头发皮质醇提取和量化.
- 统计分析包括斯皮尔曼相关性,t测试,ANOVA和多变量线性回归.
主要成果:
- 在产前期间,平均logHCC增加.
- 怀孕前的BMI显示出与HCC的一致的关联.
- 对食物获取,教育,染发和婴儿性别观察到特定时间的关联.
结论:
- 这是从LMIC中对孕妇HCC的最大研究.
- 这些发现为使用HCC作为产前HPA轴生物标志物奠定了基础.
- 这项研究支持对应激反应系统的生物标志物的开发,以改善母婴健康.
相关概念视频
Hormones of the Adrenal Glands
2.4K
Adrenal hormones play a pivotal role in maintaining the body's electrolyte balance and orchestrating responses to stress, showcasing the intricate functions of the adrenal cortex and medulla.
The adrenal cortex, a powerhouse of hormone synthesis, generates over two dozen corticosteroid hormones. The zona glomerulosa produces mineralocorticoids, exemplified by aldosterone, influencing the electrolyte composition of body fluids. The synthesis of glucocorticoids such as cortisol and...
The adrenal cortex, a powerhouse of hormone synthesis, generates over two dozen corticosteroid hormones. The zona glomerulosa produces mineralocorticoids, exemplified by aldosterone, influencing the electrolyte composition of body fluids. The synthesis of glucocorticoids such as cortisol and...
2.4K
Hypothalamic-Pituitary Axis
59.9K
The response to stress—be it physical or psychological, acute or chronic—involves activation of the Hypothalamic-Pituitary-Adrenal (HPA) axis. The HPA axis is part of the neuroendocrine system because it involves both neuronal and hormonal communication. Its function is to regulate homeostatic systems—metabolic, cardiovascular, and immune—providing the necessary means to respond to a stressor.
59.9K
Gonadal and Placental Hormones
1.4K
The gonads, namely the testes in males and the ovaries in females, are pivotal in producing gonadal hormones that orchestrate the intricate processes of sexual development and reproduction.
In males, testosterone is the primary gonadal androgen. It plays a central role in the maturation of male reproductive organs — the penis and testes. Additionally, testosterone is instrumental in the development of secondary sexual characteristics — a deep voice as well as facial and pubic hair...
In males, testosterone is the primary gonadal androgen. It plays a central role in the maturation of male reproductive organs — the penis and testes. Additionally, testosterone is instrumental in the development of secondary sexual characteristics — a deep voice as well as facial and pubic hair...
1.4K
Ovarian Cycle
1.1K
The menstrual cycle includes a critical component known as the ovarian cycle, which undergoes two main phases each month—the follicular phase and the luteal phase. The follicular phase is variable and averaging around 14 days. Ovulation, triggered by a surge in luteinizing hormone (LH), marks the transition between the two phases. The second phase, the luteal phase, is relatively consistent, lasting approximately 14 days, and is marked by the activity of the corpus luteum. While a cycle...
1.1K
Adrenal Gland Disorders
1.5K
Adrenal gland disorders manifest when the production of adrenal hormones deviates from the norm, resulting in either excessive or insufficient concentrations.
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...
1.5K
Major Hormones and Their Functions
375
Hormones, the biochemical messengers produced by endocrine glands, are pivotal in regulating bodily functions and maintaining homeostasis. Each hormone's balance is crucial; imbalances can lead to significant physiological disruptions. Major hormones include oxytocin, cortisol, epinephrine, estrogen, testosterone, thyroxine, growth hormone, insulin, and glucagon.
Oxytocin, produced in the hypothalamus and released by the pituitary gland, plays a role in social bonding, childbirth, and...
Oxytocin, produced in the hypothalamus and released by the pituitary gland, plays a role in social bonding, childbirth, and...
375

