在两种Lycoris物种中,不同的真菌群落影响着对立的加兰他胺积累模式
Ziying Wang1, Jie Yuan2, Ren Wang3
1Institute of Botany, Jiangsu Province and Chinese Academy of Sciences, Nanjing 210014, China.
Microbiological research
|June 8, 2024
概括
来自高胺的Lycoris aurea的真菌内细胞可以促进Lycoris radiata中的胺生产. 这一发现为增加这种阿尔茨海默氏症的供应提供了新的策略.
科学领域:
- 植物科学 植物科学
- 菌类学 菌类学是指菌类学.
- 生物技术是生物技术.
背景情况:
- 关键的阿尔茨海默病药物加兰他主要来自Lycoris radiata,但其低含量需要其他来源.
- 金色红天然含有更高的胺含量,具有增强生产的潜力.
研究的目的:
- 来识别L. aurea的真菌内细胞,可以增加L. radiata中的胺胺积累.
- 了解这些内植物影响类生物合成的机制.
主要方法:
- 在L. radiata和L. aurea中对真菌群落的比较分析.
- 隔离和注射特定的真菌内细胞进入L. radiata.
- 在受治疗的植物中量化加兰他胺和其他Amaryllidaceae类化物 (AAs).
- 下游生物合成途径的基因表达分析.
主要成果:
- 从L. aurea中分离出的几种真菌内细胞显著增强了L. radiata中的胺积.
- 这些内植物特别增强了兰胺,而不会影响其他AA.
- 观察到AA生物合成途径下游基因的上调,这表明前体重新分配.
结论:
- 来自L. aurea的真菌内细胞可以被利用来特别增强L. radiata.中的胺生产.
- 这种方法提供了一种可持续的方法来增加胺供应并降低生产成本.
- 这项研究强调了内菌在调节植物二次新陈代谢中的潜力,用于制药应用.
关键词:
菌内细胞是真菌的内细胞.加兰他氨酸是什么?在 ITS amplicon 测序系统中,黄金花 (Lycoris aurea) 是一种黄金花.这种植物叫做Lycoris radiata.机制 机制 机制更多相关视频
06:58Author Spotlight: Evaluation of Entomopathogenic Fungi in Wild Monochamus alternatus Populations for Biocontrol Applications in Forest Wood Borers
Published on: September 29, 2023
710
07:00Microbiota of Attine Ants' Gardens: Visualizing a Microbial Landscape by Scanning Electron Microscopy
Published on: October 4, 2024
577
相关概念视频
Inducible Operons: lac Operon
The lac operon in Escherichia coli is a model for understanding inducible gene regulation and metabolic flexibility. It integrates local control by lactose and global regulation through catabolite repression, enabling E. coli to preferentially metabolize glucose when available and switch to lactose utilization when glucose is scarce.Structure and Function of the lac OperonThe lac operon contains three structural genes: lacZ (β-galactosidase), lacY (lactose permease), and lacA (thiogalactoside...
Bacterial Phylum Actinobacteria
Coryneform bacteria are gram-positive, aerobic, nonmotile rods that exhibit irregular, club-shaped, or V-shaped arrangements. Their V-shape results from snapping division, where the inner cell wall layer forms the cross-wall, while the outer layer remains intact until it ruptures on one side, causing the daughter cells to bend away.The primary genera are Corynebacterium and Arthrobacter. Corynebacterium includes diverse species, ranging from saprophytes to pathogens like Corynebacterium...
Evolution of New Traits in Microbes
Microorganisms evolve rapidly due to their large population sizes and short generation times, often exhibiting measurable changes within days under laboratory conditions. Natural selection acts on standing genetic variation, enabling the retention and amplification of beneficial traits that confer fitness advantages in changing environments.Adaptive Pigment Regulation in RhodobacterIn Rhodobacter, a genus of purple non-sulfur bacteria, light-harvesting pigments such as bacteriochlorophyll and...
Microbial Interactions: Mutualism
Mutualism is a symbiotic interaction in which all participating organisms benefit. These relationships can be obligate or facultative and are fundamental to ecosystem functions across diverse biological systems.Plant–Fungi MutualismOne well-known example is the association between plant roots and mycorrhizal fungi, such as Rhizophagus species. The fungal hyphae penetrate the root hairs and the epidermis, forming an extensive hyphal network that establishes a symbiotic association. Through this...
Microbes in the Production of Fermented Foods
Lactic acid bacteria (LAB) and molds are instrumental in fermenting plant-based foods to enhance preservation and ensure year-round availability. These microbial processes convert plant carbohydrates into organic acids and other metabolites that inhibit spoilage organisms and contribute to the sensory qualities of the final product.In sauerkraut production, cabbage goes through a microbial succession that starts with cocci such as Leuconostoc mesenteroides. These microbes begin fermentation by...
Microbiota of the Large Intestine
The large intestine hosts the most densely populated microbial ecosystem in the human body. This complex community primarily consists of anaerobic bacteria, with Bacillota (formerly Firmicutes) and Bacteroidota (formerly Bacteroidetes) as the predominant groups. The distribution of these microbes varies along different sections of the large intestine, influenced by local environmental factors such as oxygen availability and nutrient composition.The cecum, located at the beginning of the large...
