通过使用tauroursodeoxycholic acid (TUDCA) 和SCD益生菌来抑制NLRP3炎症酶,促进老年肝脏的寿命
Burcu Baba1, Taha Ceylani2, Rafig Gurbanov3
1Department of Medical Biochemistry, Yüksek İhtisas University, Ankara, Turkey.
Archives of gerontology and geriatrics
|June 8, 2024
概括
这项研究表明,tauroursodeoxycholic acid (TUDCA) 和SCD益生菌通过减少纤维化和炎症来改善老老鼠的肝脏健康. 它们还对脂质代谢和肝功能标志物产生积极影响.
科学领域:
- 生物化学和分子生物学
- 胃肠病学和肝病学
- 衰老研究研究 衰老研究
背景情况:
- 衰老与逐渐的肝损伤和对肝脏疾病的敏感性增加有关.
- 炎症酶激活在与年龄相关的肝炎和纤维化中起着关键作用.
- 针对脂质代谢和炎症的治疗策略对于管理老年人肝脏健康至关重要.
研究的目的:
- 调查SCD益生菌和tauroursodeoxycholic acid (TUDCA) 对老年雄性大鼠肝脏健康的联合和单独影响.
- 评估这些药物对生物分子组成,组织病理学和炎症细胞活性的影响.
- 探索与年龄相关的肝病的潜在治疗益处.
主要方法:
- 在一周内给老老鼠注射静脉TUDCA和口服SCD益生菌.
- 使用ATR-FTIR光谱和机器学习评估肝脏的生物分子组成.
- 通过RT-qPCR和组织学分析量化炎症酶标记物 (NLRP3,ASC,Caspase-1,IL18,IL1β).
- 组织病理学检查细胞退化,淋巴透和纤维化.
主要成果:
- 通过降低胆固醇,TUDCA 改善了脂质代谢;SCD 益生菌调节了脂质和蛋白质配置文件.
- 组织学分析显示,肝脏退化,淋巴透和纤维化显著减少.
- 炎症酶活性被抑制,这表明NLRP3和ASC免疫活性下降.
- 尽管增加了AST和LDH,但SCD益生菌增加了白蛋白水平,表明它具有保护作用.
结论:
- TUDCA和SCD益生菌在与年龄相关的肝脏疾病中显示出治疗潜力.
- 这些药物在改善肝脏健康和减少病理方面表现出个别和协同作用.
- 研究结果支持定制方法来对抗肝纤维化,增强功能,并减少老年人群的炎症.
关键词:
在ATR-FTIR中使用.纤维化 纤维化 纤维化炎症 炎症是一种炎症.肝脏 肝脏 肝脏 肝脏在NLRP3炎症酶体中,NLRP3炎症在SCD益生菌中,SCD益生菌.图德卡 (Tudca) 是一个土耳其人.更多相关视频
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