系统性硬化症患者中的COVID-19疫苗接种和感染:一种以硬化症患者为中心的干预网络 (SPIN) 队列研究
Kimberly S Lakin1, Yin Wu2, Jessica K Gordon1
1Hospital for Special Surgery, New York, New York, USA.
Seminars in arthritis and rheumatism
|June 8, 2024
概括
大多数系统性硬化症患者已完全接种了COVID-19疫苗,报告了很少的严重不良事件和持续的免疫抑制剂. 对于接种疫苗的犹往往源于对疾病爆发的担忧,尽管很少有接种疫苗的人经历过这种情况.
科学领域:
- 免疫学 免疫学 免疫学
- 类风湿病学 类风湿病学
- 传染病流行病学 传染病流行病学
背景情况:
- 系统性硬化症 (SSc) 是一种自身免疫性疾病,需要仔细管理感染和接种疫苗.
- 此前关于SSc患者COVID-19疫苗接种的数据是在2021年收集的.
- 需要更新数据来评估到2022年的疫苗接种率,安全性和结果.
研究的目的:
- 更新COVID-19疫苗接种率,包括增强剂,在成年人SSc.
- 评估疫苗相关的不良事件和疫苗接种后的SSc症状变化.
- 为了评估免疫抑制药物管理,疫苗犹和COVID-19感染的流行率和严重程度在这个队列.
主要方法:
- SPIN队列参与者在2021年4月至5月和2022年6月至7月完成了调查.
- 收集的数据包括COVID-19疫苗接种状态 (初级系列和强剂),不良事件,药物管理,疫苗犹和感染史.
- 完全接种疫苗,定义为初级系列加至少一个强剂量.
主要成果:
- 在2022年,有可用数据的参与者中有89% (437/489) 和93% (960/1033) 接种了至少一剂疫苗.
- 副作用 (手臂疼痛,疲劳) 是常见的,但不严重; 4-6%的人报告说,疫苗接种后SSc症状恶化.
- 在接种疫苗时,13-19%的人暂时停止或减少免疫抑制剂 (甲基酸/酸);56%的未接种疫苗的人表示担心SSc爆发.
- 35% (172/489) 报告COVID-19感染,其中66%发生在初级接种疫苗后;大多数感染是轻度至中度.
结论:
- 在全身性硬化症患者中观察到高的COVID-19疫苗接种率 (包括增强剂).
- 副作用通常是轻微的,并且SSc症状恶化在接种疫苗后不常见.
- 大多数患者继续接受免疫抑制疗法;疫苗的犹与SSc爆发的担忧有关,尽管实际爆发并不常见.
相关概念视频
Vaccinations
44.4K
Overview
44.4K
Factors Affecting the Risk of Infection
11.8K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
11.8K
Immunodeficiency Diseases
935
Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
There are three main causes of immunodeficiency...
935
Autoimmune Disorders
417
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
Concept and Mechanism of Autoimmune Diseases
The immune...
417
Sexually Transmitted Infections
300
Sexually transmitted infections (STIs) are diseases transmitted primarily through unsafe sexual interactions. Bacteria, viruses, or parasites cause them and can result in severe health complications if untreated.ChlamydiaThe bacterium Chlamydia trachomatis is responsible for the disease Chlamydia, the most common STI in the United States. This peculiar pathogen requires human cells to reproduce, residing intracellularly. The initial infection often goes unnoticed because it typically does not...
300
Myasthenia Gravis: Overview and Treatment
1.4K
Myasthenia gravis is a neuromuscular transmission disorder characterized by weakness and increased fatigability of skeletal muscles. It is an autoimmune disease affecting approximately one in 2000 people, where antibodies against the α1 subunit of nicotinic acetylcholine receptors are produced.
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which...
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which...
1.4K


