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电子蒙特卡洛引擎的开发和验证,用于手术内放射治疗中的应用

Luisa Rank^1,2, Peter Lysakovski¹, Gerald Major³

¹Heidelberg Ion-Beam Therapy Center (HIT), Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg, Germany.

Medical physics

|June 8, 2024

概括

蒙特雷 (MR),一个快速的蒙特卡洛剂量引擎,得到了增强,以模拟FLASH手术内辐射疗法 (IORT) 的电子和光子束. 验证确认了MR的验证.

科学领域:

医学物理医学物理
辐射瘤学辐射瘤学
计算科学计算科学

背景情况:

蒙特卡洛 (MC) 框架的开发对于即将使用Mobetron电子线性加速器进行FLASH手术内辐射疗法 (IORT) 的临床试验至关重要.
准确剂量计算的必要性对于有效和安全的IORT输送至关重要.

研究的目的:

扩展和验证内部开发的快速MC剂量引擎MonteRay (MR),用于IORT的未来临床应用.
将电子和光子束模拟纳入MR中.

主要方法:

蒙特雷 (MR) C++ MC剂量计算引擎被扩展到模拟电子和光子束.
对 MR 模拟结果与 FLUKA (一种通用 MC 代码) 进行了比较,在水中,具有异质性,以及在一个人形幻影中.
从Mobetron加速器获得的剂量计数据用于MR验证.
与FLUKA.MR的运行时间进行了评估.

主要成果:

电子束在水中的MR剂量分布与FLUKA一致,在2.3%以内,范围值在0.01mm以内.
计算的MR剂量值在水幽灵测量数据的3%以内.
马通过率超过99.8% (1%/1毫米) 与不均性和99.4% (3%/2毫米) 在一个人造幻影.
与FLUKA相比,MR显示了大约13倍的加速度,用于10 MeV电子.

结论:

对FLUKA和实验数据的验证证实了MR的物理模型适合IORT.
在IORT中,MR是用于剂量计算的验证工具.
未来的工作包括将MR与FLASH生物剂量预测的生物物理模型进行接口.

关键词:

蒙特卡罗的蒙特卡罗是一个非常好的城市.蒙特雷雷是一个蒙特雷雷.电子电子电子的电子是什么发动机的发动机发动机的发动机.在手术内进行的手术.莫比特朗是什么意思辐射疗法辐射疗法

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