解读TCF19/miR-199a-5p/SP1/LOXL2通路:对乳腺癌转移和上皮-介质细胞过渡的影响
Shu-Yu Li1, Nan Zhang2, Hao Zhang3
1Department of Thyroid and Breast Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China.
Cancer letters
|June 8, 2024
概括
这项研究确定TCF19是通过TCF19/miR-199a-5p/SP1/LOXL2通路的乳腺癌转移的关键驱动因素. 针对这一轴为新乳腺癌治疗提供了潜在的潜力.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 遗传学 遗传学 是一个
背景情况:
- 乳腺癌 (BC) 是癌症死亡的主要原因,主要是由于转移.
- 表皮-介质细胞过渡 (EMT) 对于癌细胞迁移和入侵至关重要.
- 识别调节EMT的新型基因对于理解BC进展至关重要.
研究的目的:
- 研究TCF19在乳腺癌转移中的作用.
- 阐明TCF19介导的EMT的分子机制.
- 在BC.探索TCF19/miR-199a-5p/SP1/LOXL2轴.
主要方法:
- 计算分析以确定与EMT相关的基因.
- 在BC细胞系中进行体外验证.
- 在体内异种移植模型 (皮下和尾静脉).
- 基因组分析以评估基因丰富.
主要成果:
- 在BC中,TCF19被确定为一个关键的EMT相关基因.
- 在TCF19/miR-199a-5p/SP1/LOXL2轴促进BC细胞迁移,入侵和EMT.
- 通过降低miR-199a-5p的调节和改变SP1结合,TCF19增强了LOXL2的表达.
- 在体内,TCF19和LOXL2促进瘤生长和转移.
结论:
- 在乳腺癌中发现了一种新的EMT诱导途径,TCF19/miR-199a-5P/SP1/LOXL2.
- TCF19在驱动BC恶性瘤和转移方面发挥着关键作用.
- 这一途径为BC干预提供了潜在的治疗目标.
相关概念视频
Metastasis
5.5K
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
5.5K
Canonical Wnt Signaling Pathway
8.7K
The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which...
8.7K
Non-Canonical Wnt Signaling Pathways
7.3K
Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...
7.3K
The Tumor Microenvironment
6.6K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.6K
TGF - β Signaling Pathway
7.3K
The TGF-β signaling pathway regulates cell growth, differentiation, adhesion, motility, and development. TGF-β ligands that induce TGF-β signaling are synthesized in their latent form. Several proteases or cell surface receptors such as integrins act upon the latent form, releasing the active ligand. There are three types of mammalian TGF-βs: (TGF-β1, TGF-β2, and TGF-β3) that bind as homodimers or heterodimers to TGF-β receptors. The TGF-β receptors...
7.3K
Mitogens and the Cell Cycle
6.5K
Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
6.5K


