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Updated: Jun 17, 2026

Nanomechanics of Drug-target Interactions and Antibacterial Resistance Detection
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设计和合成一个C8替代硫胺氨酸库,以探测细菌的透性

Okan Yildirim1, Dipti Barman1, Mia Chung1

  • 1Chemical Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.

Bioorganic & medicinal chemistry letters
|June 8, 2024
PubMed
概括

研究人员开发了新的C8替代硫胺氨酸类似物,以研究阴性细菌的透性. 这有助于通过理解结构-透性关系来设计抗生素发现的预测工具.

关键词:
抗生素耐药性 抗生素耐药性面向多样性的综合研究.药物发现 药物发现格拉姆阴性细菌是一种细菌.核酸类比的核酸类比

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Aminoglycosides constitute a highly potent class of bactericidal antibiotics that exert their antimicrobial effects by targeting the bacterial ribosome, specifically disrupting protein synthesis. These polycationic molecules consist of amino-modified sugars linked via glycosidic bonds to an aminocyclitol core such as 2-deoxystreptamine or streptamine. Their strong positive charges facilitate tight binding to the negatively charged phosphate backbone of ribosomal RNA (rRNA), primarily at the 16S...