超越风险的窗口? 荷兰双极子孙研究:22年的随访
Fleur G L Helmink1, Esther Mesman1, Manon H J Hillegers1
1Erasmus MC Sophia Children's Hospital, Rotterdam, the Netherlands.
概括
双相情感障碍 (BD) 的父母的后代在青春期面临BD的最高风险. 然而,其他情绪障碍的风险持续到中年,强调需要持续监测和早期干预.
科学领域:
- 精神病学是一个精神病学.
- 遗传学 遗传学 是一个
- 发展心理学 发展心理学
背景情况:
- 父母患有双相情感障碍 (BD) 的青少年后代患有BD和其他精神病理的风险较高.
- 了解这个人群中年期的长期风险轨迹对于有效的干预策略至关重要.
研究的目的:
- 确定与双相情感障碍 (BD) 和父母患有BD的后代其他精神病理的特定与年龄相关的风险窗口.
- 为了检查情绪障碍的过程从青春期到中年成人在一个家庭高风险队列.
主要方法:
- 这项研究是对荷兰双极子女研究的22年后续研究,该研究是1997年启动的固定队列.
- 在基线和1年,5年,12年和22年间隔对100个子女 (平均年龄38.28岁) 的评估,父母患有双相I或II型精神障碍.
- 利用诊断面试来追踪情绪障碍和其他精神病理的发病和复发.
主要成果:
- 在12年的随访后,没有观察到新的双相情感障碍 (BD) 发病,终身患病率为11% -13%.
- 任何情绪障碍的终身患病率为65%,主要抑郁障碍为36%,复发性情绪发作为37%.
- 在最终评估之前的十年中,主要抑郁症的患病率翻了一番,71%的后代寻求心理健康服务.
结论:
- 父母患有双相情感障碍 (BD) 的后代患双相情感障碍 (BD) 发病的最高风险发生在青春期.
- 其他情绪障碍和复发的风险持续到中年,这强调了终身监测的必要性.
- 较轻微的精神病理形式往往先于严重的情绪障碍,强调了在家族高风险人群中早期识别和干预的重要性.
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