儿童免疫受损宿主中的传染性并发症:叙述性综述
Thomas Lehrnbecher1, Andreas H Groll2
1Department of Paediatrics, Division of Haematology, Oncology and Hemostaseology, Goethe University Frankfurt, Frankfurt Am Main, Germany.
概括
感染严重影响免疫缺陷儿童. 本综述强调了诊断,管理和跟踪这些脆弱儿童感染并发症的关键儿科方面.
科学领域:
- 儿童传染病 儿童传染病
- 免疫学 免疫学 免疫学
- 血液学-瘤学 血液学-瘤学
背景情况:
- 感染是导致疾病和初级或二级免疫缺陷儿童不良结果的主要原因.
- 在早期检测和治疗原发性免疫缺陷方面的进展是显著的.
- 传染性并发症对患有癌症的儿童构成重大风险.
研究的目的:
- 审查针对免疫功能低下儿童感染的临床影响,诊断,管理和随访的儿科特异性考虑.
- 为应对小儿抗菌药物开发和批准方面的挑战.
- 强调长期随访和晚期影响在免疫功能低下的儿科患者的重要性.
主要方法:
- 关于PubMed文章的叙述性回顾,截至2024年1月.
- 从已识别的文章中搜索引用.
- 包括搜索术语:感染,免疫缺陷,癌症,诊断,抗菌剂,细菌,真菌,病毒和随访.
主要成果:
- 诊断工具需要针对儿科的具体适应,例如尽量减少辐射暴露.
- 开发抗微生物药物和适当的儿科剂量仍然是重大挑战.
- 长期跟踪和晚期影响的影响对于免疫力低下的儿童至关重要.
结论:
- 在过去的30年里,免疫力低下儿童的传染病支持性护理有了显著的改善.
- 国际合作对于解决这种儿科患者群体中独特的挑战至关重要.
- 需要继续专注于针对免疫功能低下的儿童和青少年的专业护理.
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