在中国肺结核患者的密切接触者中结核感染:基于人口的多中心研究
Canyou Zhang1, Yushu Liu1, Yuxia Yao2
1National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Center for Tuberculosis Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
结核病感染 (TBI) 在中国肺结核病患者的密切接触者中非常普遍. 年龄较大,接触时间较长和共享卧室显著增加TBI风险,突出了针对性接触追踪的必要性.
科学领域:
- 公共卫生 公共卫生
- 传染性疾病 传染性疾病
- 流行病学 流行病学
背景情况:
- 关于中国肺结核患者的密切接触者中结核感染 (TBI) 患病率和风险因素的数据有限.
- 结核病患者的密切接触者代表了结核病传播的高风险人群.
研究的目的:
- 估计中国PTB患者的密切接触者中TBI的患病率.
- 在这个高风险群体中确定与结核病传播相关的风险因素.
主要方法:
- 一个多中心,集群随机对照试验确定了PTB患者及其密切接触者.
- 使用QuantiFERON-TB金管内测试 (QFT) 来测试TBI的接触者.
- 计算了TBI的患病率和风险因素的几率比率 (ORs).
主要成果:
- 该研究确定了3138例PTB指数病例和8117名密切接触者.
- 在与活跃PTB接触者中观察到443.51例/100,000人口的TBI患病率.
- 在39.12%的接触者中发现了QFT阳性,并且与年龄较大,接触时间较长和共享卧室显著相关.
结论:
- 在中国,PTB患者的密切接触者中存在大量的TBI负担.
- 接触者追踪和TBI调查对于管理结核病传播至关重要.
- 老年人,长期接触者和共用卧室的人是干预的优先组.
更多相关视频
09:34An Automated Culture System for Use in Preclinical Testing of Host-Directed Therapies for Tuberculosis
Published on: August 16, 2021
09:54Synthesis, Characterization, and Application of Superparamagnetic Iron Oxide Nanoprobes for Extrapulmonary Tuberculosis Detection
Published on: February 16, 2020
相关概念视频
Pulmonary Tuberculosis I
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Pulmonary Tuberculosis V
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
Pulmonary Tuberculosis IV
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
Pulmonary Tuberculosis III
The first classification is based on the development of the disease, and it includes the following categories:
Pulmonary Tuberculosis II
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Transmission-based Precautions II: Airborne and Protective Environment
Airborne precautions:
Use airborne precautions when treating patients known or suspected to have diseases that spread through the air—for example, tuberculosis or measles. These organisms are present in smaller droplets expelled by an infected person and...
