纳米粒子-凝复合物作为双药物输送系统,用于角膜移植排斥的潜在应用
Xiaoning Xu1, Yuqin Wu1, Ruiling Gu1
1National Engineering Research Center of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical University, Wenzhou 325027, China.
概括
一种新型的双药水凝输送系统,载有拉巴素 (RAPA) 和利沃素化物 (Lev),增强了眼睛的生物可用性,可能减少角膜移植的排斥,改善移植的存活率.
科学领域:
- 眼科医生 眼科 眼科
- 生物材料科学 生物材料科学
- 药物输送系统 药物输送系统
背景情况:
- 角膜移植失败主要是由免疫排斥引起的.
- 目前使用免疫抑制剂 (如拉巴素 (RAPA)) 和抗生素 (如利沃素化物 (Lev)) 的治疗方法具有有限的眼部生物可用性和副作用.
研究的目的:
- 开发一种双重药物输送系统,使用加性基水凝 (NapFFKK) 加载了拉帕素 (RAPA) 微粒和利沃素化物 (Lev).
- 通过提高眼部药物生物可用性来评估该系统在减少角膜移植排斥方面的潜力.
主要方法:
- 制造一个Lev@RAPA微粒加载的基离子基水凝 (NapFFKK).
- 使用传输电子显微镜和体力测量,对水凝特性进行表征.
- 评估体外药物释放,眼睛耐受性和前角膜保留时间.
主要成果:
- 装载在Lev@RAPA小粒中的NapFFKK水凝显示了持续的体外药物释放.
- 水凝表现出良好的眼睛耐受性和延长的角膜前保留 (>60分钟).
- 观察到Lev和RAPA的眼部生物可用性显著提高.
结论:
- 开发的双药物输送系统显示,它有望抑制角膜移植排斥.
- 这种配方可以通过提高药物输送和疗效,为角膜移植提供改进的治疗策略.
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