用于人类消费的水果来源的药用和食用草药的安全性:系统性审查
Huilin Liu1, Xianjie Feng2, Rui Zhang2
1Graduate School, Jiangxi University of Chinese Medicine, Nanchang, China.
Journal of ethnopharmacology
|June 8, 2024
概括
传统中医药 (饮食疗法) 中药用和食用水果的安全性尚未完全确立. 这次审查在12种水果物种中发现了不良事件 (AE) 和严重不良事件 (SAE),强调需要谨慎.
科学领域:
- 药理学和毒理学 药理学和毒理学
- 民族植物学 民族植物学
- 食品安全 食品安全
背景情况:
- 药用和食用水果是中国传统医学 (饮食疗法) 的组成部分.
- 目前的消费缺乏安全指南,需要对潜在的不良事件 (AE) 进行评估.
研究的目的:
- 系统审查和评估30种药用和食用水果的人类消费的安全性.
- 识别和分类与这些水果相关的不良事件 (AE) 和严重不良事件 (SAE).
主要方法:
- 搜索了七个数据库,查找与药用和食用水果相关的不良事件 (AE) 报告,截至2023年5月31日.
- 如果AE危及生命或导致严重残疾,则将AE分类为严重AE (SAE).
- 使用四级系统评估水果消费和AEs之间的因果关系:"确定"",可能"",可能"或"不太可能".
主要成果:
- 三十个AE报告涉及12种水果物种;18种没有报告的AE.
- 记录了97个副作用,主要是胃肠道症状,过敏反应和神经精神影响.
- 三十个SAEs被记录在内,其中Zanthoxyli pericarpium,Perillae fructus和Anisi stellati fructus的发病率最高;一个死亡与Mori fructus有关.
结论:
- 十二种药用和食用水果物种有相关的副作用,因果关系从"可能"到"确定"不等.
- 严重的不良事件 (SAE) 是常见的,通常与过量剂量,长时间使用或给婴儿/幼儿的使用有关.
- 某些药用和食用水果的安全性需要进一步调查和更明确的消费指南.
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