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Updated: Jul 17, 2026

Screening for Endocrine Activity in Water Using Commercially-available In Vitro Transactivation Bioassays
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在代表性哺乳动物,鸟类和鱼类中选800种假定的内分泌干扰化学物质,使用一种神经化学无细胞测试平台

Krittika Mittal1, Adeline Arini1, Niladri Basu1

  • 1Department of Environmental Health Sciences, University of Michigan, Ann Arbor, MI, USA; Faculty of Agricultural and Environmental Sciences, McGill University, Montreal, QC, Canada.

Chemosphere
|June 8, 2024
PubMed
概括

这项研究开发了一种高通量无细胞试验,用于选鸟类,哺乳动物和鱼类内分泌干扰的化学物质. 该平台确定了453种化学相互作用,突出了对环境安全的潜在生态毒性风险.

关键词:
生态毒理学 生态毒理学新方法的方法新方法的方法.风险评估 风险评估 风险评估查检测试验 查检测试验毒性测试是指对毒性的测试.

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Toxicity Testing in Animals01:23

Toxicity Testing in Animals

Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...