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在STC模型小鼠中,通过调节5-HT4/cAMP/PKA/AQP4信号通路对结肠过渡功能产生石酸的影响和机制

Zhuoli Yu¹, Lalai Zikela¹, Dingli Wang¹

¹School of Public Health, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.

The Journal of nutritional biochemistry

|June 8, 2024

概括

在Torreya grandis油中发现的天酸 (SA) 在小鼠中改善了慢过渡便秘 (STC). SA使肠道微生物群正常化并激活了5-HT4 / cAMP / PKA / AQP4通路,为STC提供了潜在的治疗方法.

科学领域:

胃肠病学胃肠病学
药理学药理学是指药理学的学科.
微生物组学微生物组学

背景情况:

众所周知,Torreya grandis油有助于缓慢过渡便秘 (STC).
这种油的关键成分 - - 石酸 (SA) 在STC病理进展中的特殊作用需要进一步阐明.

研究的目的:

为了研究石酸 (SA) 对缓慢过渡性便秘 (STC) 的治疗作用.
探索SA影响STC的潜在分子和微生物机制.

主要方法:

使用洛佩拉米德诱导了一种STC小鼠模型.
小鼠被SA治疗了两周,随后对生理参数,结肠病理,基因表达 (5-HT4 / cAMP / PKA / AQP4通路) 和肠道微生物群组成 (16S rRNA测序) 的评估进行了评估.

主要成果:

SA治疗显著改善了STC诱导的体重减轻和肠道运动率的降低.
SA改善了血指数,减少了结肠损伤,并恢复了5-HT4 / cAMP / PKA / AQP4信号通路的表达.
SA调节了肠道微生物群,降低了Firmicutes/Bacteroidetes的比率,并增加了像Akkermansia这样的有益细菌.

结论:

石酸 (SA) 在慢过渡便秘 (STC) 的小鼠模型中有效缓解结肠功能障碍.
治疗效果与5-HT4/cAMP/PKA/AQP4信号通路的激活以及肠道微生物群的正常化有关.
沙氨酸显示出作为STC和可能其他相关胃肠道疾病的治疗剂的潜力.

关键词:

5 - 氧三胺胺是一种5 - 水氧三胺.亚波林-4是一种亚波林-4 石酸是什么石酸是什么缓慢过渡性便秘缓慢过渡性便秘

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