在减肥期间膝关节骨关节炎患者的小腿肌肉组成变化:使用骨关节炎倡议数据进行性别特异分析
Kamyar Moradi1, Bahram Mohajer1, Soheil Mohammadi2
1Musculoskeletal Radiology, Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Osteoarthritis and cartilage
|June 8, 2024
概括
在膝关节骨关节炎 (KOA) 患者中,减肥改善了大腿肌肉质量,但女性的益处比男性少. 对于优化减肥期间肌肉健康的性别特定干预措施,需要进一步的研究.
科学领域:
- 生物医学工程 生物医学工程
- 肌肉骨健康 肌肉骨健康
- 放射学 放射学是一门学科.
背景情况:
- 减肥是膝关节关节炎 (KOA) 的一个关键干预措施.
- 在KOA患者的体重减轻期间,性别可能会影响大腿肌肉组成的变化.
- 了解这些基于性别的差异对于优化治疗至关重要.
研究的目的:
- 为了研究KOA患者体重减轻期间大腿肌质的纵向性变化.
- 为了比较女性和男性之间的肌肉内和肌肉间脂肪组织和收缩率的变化.
主要方法:
- 使用了骨关节炎倡议 (OAI) 队列数据,这些数据来自四年来放射性KOA和BMI>5%的减轻.
- 采用深度学习算法分析大腿肌肉的MRI衍生生物标志物 (内部MAT,间MAT,收缩百分比) 在基线和4年.
- 调整了包括人口统计,风险因素,BMI变化,体力活动,饮食和KOA状态在内的混因素.
主要成果:
- 分析了313个大腿 (192个女性,121个男性),两性体重减轻的情况相似.
- 与男性相比,女性在大腿肌肉质量上的有益变化较少.
- 具体来说,女性在MAT内部的下降幅度较小 (783.44 mm2/4年,P<0.001),收缩率的增加也较小 (-3.9%/4年,P=0.019).
结论:
- 在KOA患者的体重减轻导致有益的大腿肌肉质量变化,但这些变化在女性中不那么明显.
- 对潜在机制进行进一步的调查是有必要的.
- 建议制定特定于性别的干预措施,以提高KOA减肥期间的肌肉质量.
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