用放射治疗和手术治愈的头肉瘤患者的结果
Alison K Yoder1, Ahsan Farooqi1, Devarati Mitra1
1Department of Radiation Oncology, MD Anderson Cancer Center, Houston, Texas.
Practical radiation oncology
|June 8, 2024
概括
头部和部软组织肉瘤 (STSs) 的治疗时间没有影响癌症控制或毒性. 与手术前的放射治疗相比,手术后的放射治疗 (RT) 可以减少伤口并发症.
科学领域:
- 在瘤学瘤学.
- 手术瘤学手术瘤学
- 辐射瘤学 辐射瘤学
背景情况:
- 头部和部软组织肉瘤 (H&N STS) 很罕见,难以管理.
- 联合手术和放射治疗 (RT) 用于治愈目的.
研究的目的:
- 描述手术和RT治疗的H&N STS患者的结果.
- 评估RT时间对局部控制 (LC),疾病特异性存活率 (DSS) 和并发症的影响.
主要方法:
- 在1968-2020年期间接受治疗的192名非转移性H&N STS患者的回顾性审查.
- 卡普兰-梅尔生存和局部对照估计方法.
- 使用考克斯比例危险模型进行多变量分析.
主要成果:
- 术后的RT给了70%的患者,通常是高剂量.
- 术前和术后的RT序列没有影响LC或DSS.
- 积极/不确定的利率是与减少LC相关的唯一因素.
- 手术后的RT与较少的重大伤口并发症 (7.5%与22.4%) 有关.
- 在RT时间组之间,晚期毒性没有显著差异.
结论:
- 在其他位置的H&N STS中,LC比其他地方的肉瘤差.
- LC与DSS有显著的相关性.
- RT时间不会影响瘤学结果或长期毒性.
- 手术前的RT增加了重大伤口并发症的风险.
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