在子全心模型中不同抗病毒疗法的电生理学概况
Julian Wolfes1, Lina Kirchner2, Florian Doldi2
1Department of Cardiology II (Electrophysiology), University Hospital Münster, Albert-Schweitzer-Campus 1, 48149, Münster, Germany. julian.wolfes@ukmuenster.de.
Cardiovascular toxicology
|June 8, 2024
概括
抗病毒COVID-19治疗方法,如氧化和亚齐胺,显示出显著的前节律失常潜力. 洛皮纳维尔和雷德西维尔对心脏电生理学的影响较小,雷德西维尔降低了心率.
科学领域:
- 心脏病学 心脏病学
- 药理学 药理学是指药理学的学科.
- 电子生理学 电子生理学
背景情况:
- 针对COVID-19的抗病毒疗法引起了人们对潜在心脏毒性的担忧.
- 某些COVID-19治疗方法的前节律失常效应需要彻底调查.
研究的目的:
- 评估氧化,阿齐思罗米,洛皮纳维尔和雷梅西维尔对心脏电生理学的心脏毒性副作用.
- 用隔离的子心脏模型评估这些抗病毒药物的前节律潜力.
主要方法:
- 使用兰根多夫模型与51个隔离的子心脏.
- 使用内分心和上心导管进行了电生理学研究,以测量动作潜能持续时间 (APD90),QT间隔和再极化分散.
- 用氧化,氧化加上阿齐思罗米,洛皮纳维尔或雷梅西维尔在不同度下治疗心脏.
主要成果:
- 氧化chloroquine和azithromycin表现出显著的前节律潜力,主要是通过作用潜力的延长和增加复极化分散.
- 洛皮纳维尔和雷梅西维尔的电生理变化不那么明显.
- 雷梅西维尔与心室逃逸节律的显著减缓有关,与报告的心效应一致.
结论:
- 氧化和阿齐思罗米的组合构成相当大的前节律失常风险.
- 洛皮纳维尔和雷梅西维尔与氧化和阿齐思罗米相比,似乎具有更有利的心脏电生理学特征.
- 对抗病毒疗法的心脏安全性的进一步研究对于管理COVID-19患者至关重要.
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