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肠道抗体与性偏好和艾滋病毒感染有关

Elisa Rubio Garcia^1,2,3, Maria Casadellà⁴, Mariona Parera⁴

¹Department of Microbiology, CDB, Hospital Clinic, University of Barcelona, Barcelona, Spain. elrubio@clinic.cat.

BMC microbiology

|June 8, 2024

概括

艾滋病毒感染者 (PLWH) 的肠道抗体组合与微生物组特征 (如肠型和微生物基因丰富性) 以及性偏好相关. 这些因素与免疫激活和PLWH中较低的CD4+T细胞计数有关.

科学领域:

微生物学微生物学
免疫学免疫学免疫学
传染性疾病传染性疾病

背景情况:

艾滋病毒感染者 (PLWH) 面临多药耐药生物体的风险增加,原因是易感因素.
肠道微生物组是抗微生物药物耐药性决定因素 (肠道抵抗性) 的储存库,在PLWH中发生了变化,与免疫激活和HIV-1并发症有关.
以低微生物基因丰富度为特征的肠道失调与PLWH中较低的纳迪尔CD4+T细胞计数有关.

研究的目的:

为了研究PLWH肠道抵抗体的组成.
在PLWH中确定肠道微生物组特征和肠道抗体组合之间的关联.
探索宿主变量 (如性偏好) 对PLWH肠道抵抗体的影响.

主要方法:

枪支元基因组学被用来表征肠道抗体.
该研究包括129名HIV-1感染者和27名HIV-1阴性对照.
分析的重点是与宿主变量相关的抗体多样性,组成和β多样性.

主要成果:

根据HIV-1感染状况或免疫状况,没有发现抗体多样性或组成的显著差异.
肠道抗体多样性在与男性发生性关系的男性 (MSM) 中较高,具有Prevotella丰富的肠型和高微生物基因丰富度,而与没有MSM的,具有Bacteroides丰富的肠型和低微生物基因丰富度相比.
在两组之间观察到肠道耐药性β-多样性的显著差异,确定了差异丰富的抗菌素耐药性决定因素.

结论:

肠道抗体组合与微生物群肠型,微生物基因丰富度和PLWH中的性偏好有显著的相关性.
这些与宿主相关的微生物组特征以前与免疫激活和较低的纳迪尔CD4+T细胞数量有关,这是与艾滋病毒相关的并发症的预后因素.
这项研究为艾滋病毒感染者的抗生素耐药性和临床特征之间的相互作用提供了新的见解.

关键词:

抗微生物耐药性抗微生物耐药性我们的肠道微生物组.肠道抗体体对肠道进行抵抗.艾滋病毒感染艾滋病毒感染一把枪的元基因组学.

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