后COVID的表型表现与新发精神疾病的关联
Ben Coleman1,2, Elena Casiraghi3,4, Tiffany J Callahan5
1The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA.
COVID-19 (PASC-AMs) 后的非精神病症状与新精神病诊断的更高风险有关. 神经和心血管PASC-AM显示出最强的关联,有助于对COVID后精神健康状况的风险分层.
科学领域:
- 医学研究 医学研究
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- SARS-CoV-2感染 (PASC) 后急性后续包括急性COVID-19后的各种症状.
- 以前的研究表明,在COVID-19后出现新的精神病诊断的风险增加.
- 非精神病学PASC-AM和新的精神病学诊断之间的关联仍然不清楚.
研究的目的:
- 调查非精神病PASC相关表现 (PASC-AMs) 是否会增加COVID-19后新发精神病的风险.
- 确定与精神疾病发病率相关的特定PASC-AM类别.
- 为了告知SARS-CoV-2感染后精神疾病的风险分层.
主要方法:
- 追溯电子健康记录 (EHR) 是对2,391,006名急性COVID-19患者的队列研究.
- 数据来源于国家COVID队列协作 (N3C).
- 后勤回归分析评估了151个非精神病PASC-AM (28-120天感染后) 和新的精神病诊断之间的关联,控制共变量.
主要成果:
- 在精神疾病诊断和五种类型的PASC-AMs之间发现了显著的关联.
- 观察到的神经 (1.31),心血管 (1.29) 和宪法 (1.23) PASC-AMs 的最高几率比率.
- 在不同的精神病诊断中,个别的临床特征在不同精神病诊断中存在显著差异.
结论:
- 非精神病PASC-AM与新诊断的精神病发病率增加有关.
- 这些发现突显了COVID-19对心理健康的多系统影响.
- 需要进一步的前性研究来证实这些关联并完善风险评估策略.
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