环境微生物群的多样性和稳定性是抗菌素耐药性基因积累的障碍
Uli Klümper1, Giulia Gionchetta2, Elisa Catão3,4
1Technische Universität Dresden, Institute for Hydrobiology, Dresden, Germany.
Communications biology
|June 8, 2024
概括
微生物多样性可以防止抗微生物耐药性 (AMR) 在森林等稳定的环境中传播. 土壤中较高的生物多样性减少了抗微生物耐药基因的丰富性和数量,作为自然屏障.
科学领域:
- 环境微生物学环境微生物学
- 生态生态学 生态生态学
- 抗微生物耐药性 抗微生物耐药性
背景情况:
- 抗微生物药物耐药细菌 (ARB) 和基因 (ARG) 可以殖民新的息地,如果他们克服生物耐药性.
- 微生物多样性被假设通过减少可用来限制移民ARB和ARG的建立.
研究的目的:
- 调查微生物多样性作为阻碍抗微生物耐药性传播的障碍的作用.
- 确定微生物多样性是否会影响不同环境中的抗菌素耐药性的持续性.
主要方法:
- 在具有较低人为影响的森林土壤和河床上进行了一项泛欧洲采样活动.
- 使用元基因组测序和多样性分析来评估微生物群落和ARG丰度.
- 在微生物多样性指数和ARG相对丰度之间进行了统计相关性.
主要成果:
- 在森林土壤中,更高的微生物多样性,均性和丰富性与超过85%的ARG相对丰度显著负相关.
- 每个土壤样本检测到的ARG的数量与微生物多样性相反相关.
- 在动态的河床环境中,没有观察到微生物多样性和ARG之间的显著相关性.
结论:
- 微生物群的多样性作为一种天然障碍,防止抗菌素耐药性在像森林土壤这样的静止,结构化的环境中传播.
- 长期的,基于多样性的弹性可以在稳定的息地中演变,限制抗菌素耐药性的传播.
- 微生物多样性对抗菌素耐药性的影响取决于息地的稳定性和结构.
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