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相关概念视频

Pharmacovigilance01:19

Pharmacovigilance

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Post-marketing surveillance is a critical component of pharmaceutical regulation, often uncovering unanticipated adverse drug reactions (ADRs) once a drug is widely used over an extended period.
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
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相关实验视频

Updated: Jun 24, 2025

Demonstration of the Sequence Alignment to Predict Across Species Susceptibility Tool for Rapid Assessment of Protein Conservation
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对SEND数据的交叉研究分析:毒性概况分类.

Mark A Carfagna1, Cm Sabbir Ahmed2,3, Susan Butler2,3

  • 1Eli Lilly & Company, Indianapolis, IN 46285, United States.

Toxicological sciences : an official journal of the Society of Toxicology
|June 9, 2024
PubMed
概括
此摘要是机器生成的。

一个新的平台将毒理学数据标准化,使交叉研究分析能够识别特定化合物的毒性概况和潜在的目标效应. 这有助于更好地理解多项体内研究中的药物安全性.

关键词:
发送 发送 发送计算毒理学计算毒理学交叉研究分析分析.毒性概况 毒性概况 毒性概况

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科学领域:

  • 毒理学 毒理学 毒理学
  • 数据科学数据科学数据科学
  • 药理学 药理学是指药理学的学科.

背景情况:

  • 由于缺乏标准化的数字数据格式,对体内毒理学研究的大规模分析受到阻碍.
  • CDISC SEND标准有助于多实验室数据分析,但需要协调和转换策略.

研究的目的:

  • 开发一个用于毒理学数据转换,协调和分析的平台,以改善独特发现的识别.
  • 实现自动交叉研究分析,以了解化合物的毒性概况,并评估目标和非目标效应.

主要方法:

  • 开发了数字和分类SEND数据的数据协调和转换策略.
  • 利用来自BioCelerate数据库的四个非识别的SEND数据集进行分析.
  • 创建了一个交叉研究分析仪表板,带有可视化和用户定义的评分系统.

主要成果:

  • 使用SEND域建立了关键器官系统 (肝脏,脏,男性生殖道,内分泌,造血) 的毒性概况.
  • 证明了针对相同途径的两个化合物的交叉研究分析.
  • 分析表明,在肝脏,脏和造血系统中存在潜在的目标毒性.

结论:

  • 开发的平台为科学家提供了工具,可以使用SEND.com在多项研究中比较毒性概况.
  • 自动交叉研究分析提高了对化合物特异性毒性和对标效应的理解.