在视网膜色素炎中,视神经头部的多模式成像
Naoko Wada1, Seiji Takagi1, Akiko Yoshikawa1
1Department of Ophthalmology, School of Medicine, Toho University, Tokyo, Japan.
Seminars in ophthalmology
|June 9, 2024
概括
在视网膜色素炎 (RP) 中,视神经头部 (ONH) 白与血液流量减少和视网膜神经纤维层 (RNFL) 和细胞复合体 (GCC) 厚度较薄有关. 这些发现表明,ONH白反映了RP患者更广泛的视网膜退化.
科学领域:
- 眼科医生 眼科 眼科
- 视网膜退化 视网膜退化
- 神经眼科神经眼科
背景情况:
- 视神经头部 (ONH) 白是视网膜色素炎 (RP) 的一个公认的特征.
- 在RP中ONH白的临床意义需要进一步的前性调查.
研究的目的:
- 在视网膜色素炎 (RP) 患者中前性评估视神经头部 (ONH) 特性.
- 调查ONH白与包括血流,RNFL厚度和GCC厚度在内的参数之间的关系.
主要方法:
- 底部摄影和光学连贯性断层扫描 (OCT) 用于评估ONH白和超反射结构.
- 经过CT评估了RNFL厚度和GCC,而激光斑点流图测量了ONH血流 (MV和MT).
主要成果:
- 在35%的RP眼睛中观察到ONH白,但与超反射结构没有显著的相关性.
- 患有ONH白的患者显示ONH面积,血流 (MV,MT),RNFL厚度和GCC厚度显著下降.
- 两组之间没有发现圆形区域 (EZ) 宽度的显著差异.
结论:
- 在RP中ONH白与眼睛血流减少和神经视网膜层稀薄有关.
- 这些变化表明,ONH白可能是RP中晚期视网膜退化的指标.
更多相关视频
09:20Novel Photoacoustic Microscopy and Optical Coherence Tomography Dual-modality Chorioretinal Imaging in Living Rabbit Eyes
Published on: February 8, 2018
10.8K
10:14Author Spotlight: Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration
Published on: May 26, 2023
3.1K
相关概念视频
The Retina
The retina is a layer of nervous tissue at the back of the eye that transduces light into neural signals. This process, called phototransduction, is carried out by rod and cone photoreceptor cells in the back of the retina.
Vision
Vision is the result of light being detected and transduced into neural signals by the retina of the eye. This information is then further analyzed and interpreted by the brain. First, light enters the front of the eye and is focused by the cornea and lens onto the retina—a thin sheet of neural tissue lining the back of the eye. Because of refraction through the convex lens of the eye, images are projected onto the retina upside-down and reversed.
Anatomy of the Eyeball
The eye is a spherical, hollow structure composed of three tissue layers. The outer layer — the fibrous tunic, comprises the sclera — a white structure — and the cornea, which is transparent. The sclera encompasses some of the ocular surface, most of which is not visible. However, the 'white of the eye' is distinctively visible in humans compared to other species. The cornea, a clear covering at the front of the eye, enables light penetration. The eye's middle layer, the vascular tunic,...
Photoreceptors and Visual Pathways
At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category, whereas...
Visual System
Light enters the eye through the cornea, a transparent, dome-shaped surface covering the surface of the eyeball that helps to direct and focus incoming light. This light is then channeled toward the pupil, an adjustable opening whose size is controlled by the iris. The iris, a pigmented muscle, regulates the amount of light entering the eye by contracting or dilating the pupil, thereby ensuring optimal light levels for clear vision.
Once through the pupil, the light passes through the lens, a...
Once through the pupil, the light passes through the lens, a...
Color Vision
Color perception begins in the retina, the light-sensitive layer at the back of the eye. Two main theories explain how colors are seen: the trichromatic theory and the opponent-process theory. The trichromatic theory, proposed by Thomas Young in 1802 and extended by Hermann von Helmholtz in 1852, suggests that color vision is based on three types of cone receptors in the retina. These cones are sensitive to different but overlapping ranges of wavelengths corresponding to red, blue, and green.
