试管婴儿和1型糖尿病风险:基于人口的嵌套病例控制研究
Shiue-Shan Weng1, Li-Yin Chien2
1Institute of Public Health, College of Medicine, National Yang Ming Chiao Tung University, Taipei City, Taiwan.
Human reproduction (Oxford, England)
|June 9, 2024
概括
怀孕方式,无论是自然的,没有试管婴儿或试管婴儿的次孕,都与后代患1型糖尿病的风险增加无关. 这项大型研究发现,在不同怀孕组之间,糖尿病风险没有显著差异.
科学领域:
- 生殖医学 生殖医学
- 内分泌学 在内分泌学.
- 儿科健康 儿科健康
背景情况:
- 通过体外受精 (IVF) 出生的孩子可能有较高的代谢功能受损的风险.
- 之前的研究表明,试管婴儿怀孕的孩子可能会有代谢差异.
研究的目的:
- 调查受孕方式 (自然,没有试管婴儿或试管婴儿的次生育) 是否影响后代患1型糖尿病的风险.
主要方法:
- 一项以人口为基础的,嵌套的病例控制研究利用了来自2,228,073个父子三位一体 (2004-2017年) 的台湾注册表数据.
- 怀孕模式被分为自然,次生育/非试管婴儿和试管婴儿.
- 使用ICD代码识别了1型糖尿病的诊断,病例与四个对照组相匹配.
主要成果:
- 在超过1430万人年的随访中,1型糖尿病的发病率在自然 (5.33),次生育/非试管婴儿 (5.61) 和试管婴儿 (4.74) 怀孕组中相似.
- 与自然受孕相比,没有发现低生育/非试管婴儿 (aOR 1.04) 或试管婴儿 (aOR 1.00) 的1型糖尿病风险有显著差异.
- 不孕源和胚胎类型没有显著改变1型糖尿病风险.
结论:
- 包括试管婴儿在内的受孕方式与后代1型糖尿病风险增加无关.
- 虽然代谢特征可能有所不同,但这似乎并不能转化为更高的儿童1型糖尿病风险.
- 由于诸如分层分析中的少量暴露病例等局限性,需要进一步研究.
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