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第三天的形态质量会影响低质量的欧卵性母细胞瘤的妊娠结果:一项回顾性队列研究
Wanjun Zhang1, Hao Shi1, Wenbin Niu1
1Reproductive Medical Center, First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Human reproduction (Oxford, England)
|June 9, 2024
概括
第三天的胚胎质量会影响低质量的胚胎胚胎细胞的妊娠结果. 建议将高质量的第3天胚胎转移,当只有低质量的胚芽细胞可用时,改善临床怀孕和活产率.
科学领域:
- 生殖医学 生殖医学
- 胚胎学 胚胎学
- 在体外受精过程中受精.
背景情况:
- 第三天胚胎的形态分类是已知的分裂阶段胚胎发育和怀孕结果的预测指标.
- 3日形态质量与妊娠结果之间的关系对于欧卵性母细胞囊仍然不清楚.
研究的目的:
- 调查第3天胚胎的形态质量是否会影响欧卵母细胞的妊娠结果.
- 为了确定第3天胚胎质量是否会影响单个胚胎细胞移植中的临床妊娠率 (CPR) 和活产率 (LBR).
主要方法:
- 对1275名接受单个欧囊母细胞移植的患者进行了回顾性队列研究.
- 患者根据第3天的胚胎形态分组:高质量 (HQ) 和低质量 (LQ).
- 使用多变量逻辑回归分析来评估第三天形态学对CPR和LBR的独立影响.
主要成果:
- 高质量 (HQ) 第三天胚胎组在统计学上显示出较高的CPR (59.73%) 和LBR (49.73%) 与低质量 (LQ) 组相比 (CPR: 49.70%,LBR: 41.21%).
- 第三天的胚胎质量与LQ芽细胞的CPR和LBR显著相关 (CPR的aOR为2.10,LBR的aOR为1.97).
- 在HQ胚胎囊的第3天形态和怀孕结果之间没有发现显著的关联.
结论:
- 第三天胚胎的形态质量显著影响低质量的欧卵性母细胞的妊娠结果.
- 当只有低质量的欧卵性胚胎细胞可供移植时,建议优先考虑来自高质量的第三天胚胎的胚胎.
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