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Oral Biofilm Sampling for Microbiome Analysis in Healthy Children
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在前1000天的慢性口腔疾病负担:代际风险因素,BRISA队列
Sângela Maria Pereira Araújo1, Gustavo G Nascimento2,3,4, Lorena Lucia Costa Ladeira1
1Postgraduate Program of Dentistry, Federal University of Maranhão, São Luís, Maranhão, Brazil.
Oral diseases
|June 9, 2024
概括
孕产妇的肥胖和糖摄入会影响后代的口腔健康,增加慢性口腔疾病负担的风险. 早期的口腔健康对长期健康至关重要,可以预测非传染性疾病.
科学领域:
- 公共卫生 公共卫生
- 孕产妇和儿童的健康
- 口腔流行病学 在口腔流行病学.
背景情况:
- 生命的前1000天对发育和疾病预防至关重要.
- 怀孕和幼儿时期的口腔健康与长期的健康结果有关.
- 了解影响口腔健康的代际因素对于公共卫生干预至关重要.
研究的目的:
- 分析子女口腔疾病负担的多因果模型.
- 研究母亲的社会经济,肥胖和生活方式因素对后代口腔健康的代际影响.
- 检查母亲口腔健康 (牙,牙周炎) 与后代早期糖暴露和超重状态之间的关联.
主要方法:
- 利用了巴西BRISA队列研究 (n=1141) 的数据.
- 采用结构方程建模来分析母婴变量之间的关联.
- 在两个时间点评估口腔健康指标,肥胖,糖消费,吸烟和饮酒:怀孕和孩子的第二年.
主要成果:
- 孕产妇肥胖 (SC=0.081,p=0.047) 和添加糖消费 (SC=0.142,p=0.041) 显示了代际相关性.
- 儿童糖消费 (SC=0.210,p=0.041) 显著增加了慢性口腔疾病负担.
- 孕妇的牙和牙周炎是相关的,妊娠期间的上行为也是如此.
结论:
- 孕妇的牙和牙周炎等口腔健康状况与其后代的口腔健康状况有关.
- 肥胖和糖类消费模式是跨代传承的,影响了儿童早期的口腔健康.
- 早期的口腔健康是未来非传染性疾病的重要预测因素,影响生命轨迹.
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