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Updated: Jun 24, 2025

Skeletal Phenotype Analysis of a Conditional Stat3 Deletion Mouse Model
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Skeletal Phenotype Analysis of a Conditional Stat3 Deletion Mouse Model

Published on: July 3, 2020

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德素E脊柱修饰对骨质细胞的作用 形态学:对N-Desmethyl和N-Methyl类型的合成和SAR研究

Hiroshi Sato1, Hayato Murase2, Yoshitaka Ishida3

  • 1Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3 Aza-Aoba, Aramaki, Aoba-ku, Sendai 980-8578, Japan; Mitsubishi Tanabe Pharma Corporation, 1-1-1, Marunouchi, Chiyoda-ku, Tokyo 100-8205, Japan.

Bioorganic & medicinal chemistry
|June 9, 2024
PubMed
概括

这项研究合成了N-脱甲基和N-甲基破坏素E类似物,揭示了特定的分子内键和胺基键配置对于维持质至关重要.

关键词:
循环类酸是一种循环类酸.自然产品 自然产品骨质结晶体是骨质结晶体综合合成 综合合成进行X射线结晶学分析.

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A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders11:47

A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders

Published on: June 8, 2014

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Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
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