在低收入和中等收入国家,环境细颗粒导致人类生育率下降
Mingkun Tong1, Hong Lu1, Huiyu Xu2
1Institute of Reproductive and Child Health, National Health Commission Key Laboratory of Reproductive Health and Department of Epidemiology and Biostatistics, Ministry of Education Key Laboratory of Epidemiology of Major Diseases (PKU), School of Public Health, Peking University Health Science Center, Beijing, China.
Environment international
|June 9, 2024
概括
暴露于细颗粒物 (PM2.5) 显著增加了低收入和中等收入国家 (LMICs) 的不孕率. 控制PM2.5污染对于保护这些地区的人类生育能力至关重要.
科学领域:
- 环境健康 环境健康
- 生殖流行病学 生殖流行病学
- 全球公共卫生 全球公共卫生
背景情况:
- 环境细颗粒物 (PM2.5) 暴露与人类生育能力的降低有关.
- 在低收入和中等收入国家 (LMICs) 中,PM2.5导致的不孕不育的负担仍未得到充分研究.
- 目前存在的PM2.5暴露-反应函数和LMIC中不孕率不足.
研究的目的:
- 调查长期PM2.5暴露与人类生育能力指标 (怀孕时间和不孕率) 之间的关联.
- 估计LMIC中PM2.5暴露导致的不孕症负担.
- 在LMICs中建立PM2.5暴露-响应函数用于生育指标.
主要方法:
- 分析了49个LMIC的100个人口和健康调查中的164,593名女性 (1999-2021).
- 使用卫星衍生估计 (ACAG) 评估PM2.5暴露.
- 应用通用倾向得分匹配和2阶段通用马模型来推导TTP和IR,然后对暴露-反应函数进行分线回归.
主要成果:
- 每增加10μg/m3的PM2.5与TTP增加1.7%和IR增加2.3%相关.
- 高度的PM2.5 (>75μg/m3) 与增加的不孕率有着强烈的关联.
- 据估计,在118个LMIC中,约有660万不育的夫妇是由于PM2.5暴露超过35μg/m3,占所有不育病例的2.25%.
结论:
- PM2.5显著导致人类不孕症,特别是在空气污染较高的地区.
- 控制PM2.5污染对于保障LMICs人类生育能力至关重要.
- 在南亚,东亚和西非等高暴露区域进行有针对性的干预是有必要的.
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