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在患有多发性硬化症的轻度残疾人中评估T25FW

Birgit Helmlinger¹, Daniela Pinter¹, Stefanie Hechenberger¹

¹Medical University of Graz, Department of Neurology, Research Unit for Neuronal Plasticity and Repair, Graz, Austria; Medical University of Graz, Department of Neurology, Graz, Austria.

Journal of the neurological sciences

|June 9, 2024

概括

定时25英尺步行 (T25FW) 有效地检测了多发性硬化症 (pwMS) 患者的步行速度差异,即使是那些残疾很小的人. 这种简单的测试揭示了与健康对照 (HC) 相比",完全门诊" pwMS 的微妙障碍.

科学领域:

神经学神经学
康复医学康复医学康复医学
临床评估临床评估

背景情况:

走路障碍是多发性硬化症 (pwMS) 患者的常见症状.
定时25英尺步行 (T25FW) 是一种简单的测试,用于评估步行能力.
在"完全门诊" pwMS 中微妙的行走差异尚未得到充分理解.

研究的目的:

评估T25FW在"完全门诊" pwMS中检测微妙的行走障碍方面的实用性.
为了比较"完全门诊" pwMS 的步行速度,与健康对照 (HC) 的不同残疾水平.

主要方法:

追溯分析650 pwMS. 的数据.
根据扩展残疾状况表 (EDSS) 的水平对患者进行分类.
在EDSS小组和年龄/性别匹配的HC之间走路速度的比较.

主要成果:

T25FW在15%的"完全门诊" pwMS (EDSS 0-3) 中发现了临床相关的行走障碍.
与HC相比,所有"完全门诊" pwMS的EDSS子组都显示出明显的步行速度下降.
与HC的步行速度差异随着残疾增加,从0.15m/s (EDSS 0) 增加到0.5m/s (EDSS 2.5-3).

结论:

T25FW对检测行走速度变化非常敏感,即使在多发性硬化症的早期阶段也是如此.
从EDSS 1开始,步行速度缺陷变得更加明显和临床上具有意义.
T25FW是监测 pwMS 中微妙的功能变化的一个有价值的工具.

关键词:

在EDSS中使用EDSS.最小的行走障碍是最小的.多发性硬化症是多发性硬化症.T25FWW 在线播放

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