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生物细菌 (Bifidobacterium animalis) 亚种的影响. 在口服抗生素给药期间,对小鼠的乳糖BB-12和酸奶
Ruchita G Uttarwar1, Solomon A Mekonnen1, Wannes Van Beeck1
1Department of Food Science & Technology, University of California, Davis, USA.
Microbiological research
|June 9, 2024
概括
像Bifidobacterium animalis BB-12和酸奶这样的益生菌可以帮助恢复由抗生素破坏的肠道微生物群平衡. 这些干预措施减轻了小鼠肠道细菌和代谢物的抗生素诱导的变化.
科学领域:
- 微生物学 微生物学
- 胃肠病学 胃肠病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 口服抗生素,如阿莫西西林-克拉夫兰酸盐 (AMC),可以破坏肠道微生物群和相关功能.
- 益生菌是微生物,可以为健康带来好处,包括预防或治疗抗生素诱导的失生症的潜力.
研究的目的:
- 调查Bifidobacterium animalis亚种乳糖BB-12 (BB-12) 和酸奶单独或组合的疗效,以减轻小鼠AMC诱导的肠道失调.
- 评估这些干预措施对肠道微生物群组成和新陈代谢的影响.
主要方法:
- C57BL/6J小鼠 (雄性和雌性) 接受了BB-12,酸奶,酸奶中的BB-12,或液,并与饮用水中的AMC同时服用了10天.
- 分析了便和便中的细菌组成 (16S rRNA基因测序) 和代谢物度 (代谢学).
- 在整个研究期间,对体重变化进行了监测.
主要成果:
- 在雄性小鼠中,AMC的使用显著降低了体重,并导致了两性肠道微生物群多样性和组成的快速,广泛的改变.
- 包括 Muribaculaceae 和 Lachnospiraceae 在内的特定细菌类被减少,而 Gammaproteobacteria (Erwiniaceae/Enterobacteriaceae) 则被AMC丰富.
- 益生菌干预 (BB-12和酸奶) 在雄性小鼠中部分恢复了体重,并调节了特定的细菌群体,减少了Erwiniaceae,增加了Streptococcaceae. 酸奶中的BB-12能使某些细胞代谢物正常化.
结论:
- 比菲多细菌 (Bifidobacterium animalis BB-12) 和酸奶显示出减轻抗生素诱导的肠道疾病的潜力.
- 这些益生菌可以影响肠道微生物群的组成和代谢概况,为抵消与抗生素相关的胃肠道障碍提供了一种策略.
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