在溶性液晶中异质的微粒溶解与液晶接口
Eliezer Y Goldmünz1, Abraham Aserin1, M Francesca Ottaviani2
1The Casali Center for Applied Chemistry, The Institute of Chemistry, The Hebrew University of Jerusalem, Edmond J. Safra Campus, Jerusalem 9190401, Israel.
Journal of colloid and interface science
|June 9, 2024
概括
乳液中的二甲 (Na-DFC) 经历结构变化,形成六角和状相. 尽管有这些变化,但由于稳定的界面结构,Na-DFC的释放仍然保持一致,使选择性分子负载成为可能.
科学领域:
- 材料科学 材料科学 材料科学
- 物理化学 物理化学
- 体科学 体科学 体科学
背景情况:
- 基于甘油单酸盐 (GMO) 的乳液在药物输送方面受到广泛研究.
- 了解乳液在药物内置时的结构行为对于受控释放至关重要.
- 二 (Na-DFC) 是一种常见的非类固醇抗炎药物.
研究的目的:
- 为了研究纳二二 (Na-DFC) 加入后基因转基因乳液中的结构变化.
- 阐明结构变化与Na-DFC的释放动力学之间的关系.
- 探索选择性分子界面加载用于药物输送的潜力.
主要方法:
- 微角X射线衍射 (SAXD) 来分析中相结构.
- 旋转探针电子磁共振 (EPR) 探测接口属性.
- 核四极共振 (NQR) 用于评估分子动力学和异构性.
- SAXD峰值配件和EPR光谱计算用于定量分析.
主要成果:
- 纳-DFC的结合诱导了从六边形到叶片半相的过渡,并增加了度.
- 尽管发生了结构性变化,但Na-DFC释放的驱动力保持不变.
- 在接口上发生了Na-DFC的选择性溶解,由极性,微度和顺序参数的变化证明.
- NQR分析表明与Na-DFC溶解相关的异质结构转变.
结论:
- 转基因乳液中Na-DFC的溶解和释放是异质的过程,由局部增加的细胞自由能量驱动.
- 在Na-DFC释放期间,接口结构保持不变,确保一致的释放速率.
- 选择性分子界面加载为先进的药物递送系统提供了一个有前途的战略.
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