基细胞激活测试在诊断阿司匹林过敏时低于挑测试
Marika Gawinowska1, Krzysztof Specjalski1, Maciej Zieliński2
1Department of Allergology, Medical University of Gdansk, Gdansk, Poland.
International archives of allergy and immunology
|June 9, 2024
概括
基激活测试 (BAT) 显示出诊断阿司匹林过敏的前景,但效果不如传统的挑测试. 虽然BAT更安全,更客观,但BAT更安全.
科学领域:
- 过敏和免疫学 过敏和免疫学
- 临床诊断 临床诊断 临床诊断
背景情况:
- 阿司匹林 (ASA) 过敏症诊断严重依赖于挑测试,这些测试具有药物干扰,住院需求和安全问题等局限性.
- 基细胞激活试验 (BAT) 是一种新兴的体外诊断工具,此前已被验证用于IgE介导的对食物,空气中的过敏原和昆虫毒素的过敏.
研究的目的:
- 为了评估阿司匹林过敏的基激活测试 (BAT) 的诊断性能.
- 为了将BAT的有效性与当前的黄金标准进行比较,口腔挑试验 (OPT).
主要方法:
- 148名怀疑阿司匹林过敏症的成年患者 (包括患有慢性疹,喘和慢性鼻炎的患者) 和10名健康对照患者被纳入.
- 对所有参与者进行了用阿司匹林 (ASA) 进行的基细胞激活测试 (BAT).
- 对研究小组进行了口服诱导试验 (OPT),累计剂量为1000毫克ASA.
主要成果:
- 在114名患者中,两项测试的结论性结果为肯定的BAT值为4.9%.
- 最佳技术证明了55.9%的灵敏度和75%的特异性,具有77%的积极预测值和54%的负预测值.
- 在慢性疹子小组中观察到最高的敏感性 (78%),而在慢性呼吸系统疾病小组中发现最高的特异性 (87%).
结论:
- 基激活测试 (BAT) 提供了安全性,药物独立性和客观性等优势,用于诊断阿司匹林过敏症.
- 然而,目前的性能指标表明,BAT低于ASA过敏诊断的既定口服挑试验 (OPT).
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