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相关概念视频

Notch Signaling Pathway03:14

Notch Signaling Pathway

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The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
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Non-Canonical Wnt Signaling Pathways01:41

Non-Canonical Wnt Signaling Pathways

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Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...
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Cell Signaling Feedback Loops01:07

Cell Signaling Feedback Loops

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Positive and negative feedback loops are crucial for regulating biological signaling systems. These feedback loops are processes that connect output signals to their inputs.
Negative feedback loops
Most signaling systems have negative feedback loops that can perform different functions such as output limiter, and adaptation.
Output limiter
Upon receiving an input signal, the cellular response rapidly increases until a threshold is reached. Beyond this threshold, a negative feedback loop...
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Formation of Muscle Fibers from Myoblasts01:13

Formation of Muscle Fibers from Myoblasts

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De novo myogenesis, or the formation of muscle fibers, begins during the early embryonic stages. The skeletal muscle is formed from somites– blocks of embryonic cell layers. The somites are further divided into dermatomes, myotomes, sclerotomes, and syndetomes. Among these, the myotomes give rise to muscle fibers.
Muscle progenitor cells (MPCs) are formed from the myotomes. MPCs express genes that encode the transcription factors Pax3 and Pax7. Along with Pax 3/7, other transcription...
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Master Transcription Regulators02:23

Master Transcription Regulators

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Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a  complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
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Role Of Notch Signalling In Intestinal Stem Cell Renewal01:12

Role Of Notch Signalling In Intestinal Stem Cell Renewal

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Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
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相关实验视频

Updated: Jun 24, 2025

Isolation of Whole Cell Protein Lysates from Mouse Facial Processes and Cultured Palatal Mesenchyme Cells for Phosphoprotein Analysis
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Isolation of Whole Cell Protein Lysates from Mouse Facial Processes and Cultured Palatal Mesenchyme Cells for Phosphoprotein Analysis

Published on: April 1, 2022

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由非编码RNA介导的双负反循环有助于牙形态发生.

Meng Sun1, Na Li2, Weixing Zhang2

  • 1Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an 710049, China; Department of Periodontology, College of Stomatology, Xi'an Jiaotong University, Xi'an 710000, China.

Cells & development
|June 9, 2024
PubMed
概括
此摘要是机器生成的。

一个涉及长非编码RNALOC102159588和microRNAmiR-133b的新型双负反循环调节了小型猪的牙发育. 这种复杂的机制通过控制亡,防止形,确保正常的牙形态发生.

关键词:
双负反循环的双负反循环.没有编码的RNAs.牙形态发生的过程.

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相关实验视频

Last Updated: Jun 24, 2025

Isolation of Whole Cell Protein Lysates from Mouse Facial Processes and Cultured Palatal Mesenchyme Cells for Phosphoprotein Analysis
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Isolation of Whole Cell Protein Lysates from Mouse Facial Processes and Cultured Palatal Mesenchyme Cells for Phosphoprotein Analysis

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Inducible and Reversible Dominant-negative DN Protein Inhibition
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Analysis of Developing Tooth Germ Innervation Using Microfluidic Co-culture Devices
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Analysis of Developing Tooth Germ Innervation Using Microfluidic Co-culture Devices

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科学领域:

  • 发展生物学 发展生物学
  • 分子生物学分子生物学
  • 遗传学 遗传学 是一个

背景情况:

  • 牙形态发生是一种由信号因子调节的复杂过程.
  • 非编码RNA在微调发育信号通路中起着至关重要的作用.

研究的目的:

  • 阐明长非编码RNA (LOC102159588) 和微RNA (miR-133b) 在小型猪牙形态发生过程中的作用.
  • 研究LOC102159588和miR-133b之间的双负反循环的调节机制.

主要方法:

  • 研究了小型猪牙发育中的LOC102159588和miR-133b之间的相互作用.
  • 通过Sp1.1.分析了miR-133b对LOC102159588转录的调节作用.
  • 研究了LOC102159588在调节miR-133b前核出口和通过出口in-5进行细胞质海绵的作用.

主要成果:

  • 在LOC102159588和miR-133b之间确定了一个双负反循环.
  • 证明miR-133b通过Sp1.1抑制了LOC102159588的转录.
  • 表明LOC102159588抑制了miR-133b的运输和功能,从而创建了一个反循环.
  • 这个循环调节内源性亡以维持正常的牙形态发生.

结论:

  • 发现的双负反循环对于小型猪的正常牙形态发生是必不可少的.
  • 在这个调节循环中发生的干扰会导致牙发育停止和形.
  • 这一发现凸显了非编码RNA相互作用在面发育中的关键作用.