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新生儿大脑的年龄依赖功能发展模式:基于fMRI的脑研究.

Zhiyong Zhao1, Yifan Shuai2, Yihan Wu3

  • 1Department of Radiology, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China.

NeuroImage
|June 9, 2024
PubMed
概括

用fMRI测量的大脑 (BEN) 表明新生儿的功能发展取决于年龄. 这种神经影像标志物受到基因的影响,并且在早产儿中显示出差异.

关键词:
年龄年龄年龄年龄年龄年龄大脑缩是大脑的缩.早期发展 早期发展基因基因 基因基因 基因基因新生儿新生儿新生儿功能磁力共振成像 (fMRI) 是一种

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科学领域:

  • 神经成像是一种神经成像.
  • 发育神经科学的发展神经科学.
  • 遗传学 是一个遗传学.

背景情况:

  • 动物研究将大脑 (BEN) 与早期大脑发育联系起来.
  • 人类新生儿大脑的功能变化和BEN的遗传基础需要进一步研究.

研究的目的:

  • 确定BEN是否能够识别人类新生儿大脑中年龄相关的功能变化.
  • 为了阐明BEN作为神经成像标记物的遗传基础.

主要方法:

  • 来自开发人类连接体项目的280名婴儿 (月经后37.5-43.5周) 的静止状态fMRI数据的分析.
  • 计算BEN地图和voxel-wise一般线性模型分析年龄,性别和早产影响.
  • 区域BEN和基因表达水平之间的相关性分析.

主要成果:

  • 沿着感觉-运动-听觉 ("SA") 轴的BEN与产后年龄 (PNA) 有正相关,与妊娠年龄 (GA) 有负相关.
  • 位于右侧的罗兰迪克部的BEN与GA和PNA相关.
  • 预产婴儿显示皮质BEN增加,特别是在视觉运动皮质,与期满婴儿相比.
  • 确定了五个与BEN相关的基因 (DNAJC12,FIG4,STX12,CETN2,IRF2BP2),这些基因参与了蛋白质折叠,突触囊泡运输和细胞分裂.

结论:

  • 基于fMRI的BEN作为人类新生儿年龄依赖的大脑功能发展的指标.
  • 特定的基因影响BEN,突出显示了这种神经成像标记物的遗传成分.