沉重的吸烟增加了肝细胞癌患者在治疗治疗后早期死亡的风险
Jaejun Lee1,2, Jong Young Choi1,2, Soon Kyu Lee1,3
1The Catholic University Liver Research Center, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Journal of liver cancer
|June 9, 2024
概括
沉重的吸烟显著增加了肝癌患者在治愈治疗后的早期死亡风险. 戒烟对于改善肝细胞癌患者的生存结果至关重要.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 在瘤学瘤学.
- 公共卫生 公共卫生
背景情况:
- 吸烟是肝细胞癌 (HCC) 的已知危险因素.
- 吸烟对HCC死亡率的影响,特别是治疗治疗后,需要进一步调查.
研究的目的:
- 评估吸烟与接受治愈治疗的HCC患者的早期死亡率之间的关联.
- 为了确定吸烟剂量是否会影响这一患者队列的整体生存期 (OS).
主要方法:
- 来自韩国初级肝癌登记处 (2015-2018) 数据的分析.
- 包括接受肝切除或射频切除的HCC患者.
- 评估吸烟的累积剂量在包装年和3年整体存活率 (OS).
主要成果:
- 强吸烟者 (≥40包年) 的3年生存率 (77.1%) 与非吸烟者 (83.3%) 相比显著降低.
- 在吸烟包年和3年生存期之间观察到剂量依赖的关系,从20包年开始风险增加.
- 严重吸烟,晚年,肝硬化,较大的瘤大小,血管侵袭和Child-Pugh类B/C被确定为3年死亡率的风险因素.
结论:
- 沉重吸烟 (>40包年) 与接受治疗治疗的HCC患者的3年生存率较差显著相关.
- 这些发现强调了戒烟对于改善肝细胞癌患者的存活率至关重要.
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