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Updated: Jun 24, 2025

Non-Viral Engineering of Primary Human T Cells via Homology-Mediated End-Joining Targeted Integration of Large DNA Templates
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工程T细胞用于癌症的未来前景.

Avery D Posey1, Regina M Young2, Carl H June2

  • 1Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Parker Institute for Cancer Immunotherapy at the University of Pennsylvania, Philadelphia, PA, USA; Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, USA.

Trends in cancer
|June 9, 2024
PubMed
概括

化学抗原受体 (CAR) T细胞疗法对固体瘤具有前景,但T细胞枯竭等挑战仍然存在. 策略,如地方区域传递和细胞因子.

关键词:
收养免疫疗法采用免疫疗法.仿制性抗原受体的仿制性抗原受体细胞因子释放综合征 细胞因子释放综合征

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