相关实验视频

Updated: Jun 24, 2025

Photodynamic Therapy with Blended Conducting Polymer/Fullerene Nanoparticle Photosensitizers

Photodynamic Therapy with Blended Conducting Polymer/Fullerene Nanoparticle Photosensitizers

Published on: October 28, 2015

在pH-可激活的长波长光敏感剂中剖析刺激动力学,用于可追溯的光动力学疗法

Yurong Liu¹, Jing Zhang¹, Xuan Zhou²

¹Department Marshall Laboratory of Biomedical Engineering, International Cancer Center, Laboratory of Evolutionary Theranostics (LET), School of Biomedical Engineering, Shenzhen University Medical School, Shenzhen University, Shenzhen, 518055, China.

Angewandte Chemie (International ed. in English)

|June 9, 2024

概括

研究人员开发了基于的长波长光敏化剂 (PSs),用于光动力学疗法 (PDT). 新的LET-I探针可以通过降低激光功率和增强成像来有效地根除瘤,从而改善患者的治疗结果.

科学领域:

生物医学工程生物医学工程
摄影化学的使用.
材料科学材料科学材料科学

背景情况:

传统的光动力学疗法 (PDT) 面临着系统性光毒性和有限的组织透的挑战,原因是光敏剂 (PSs) 的长波长 (LW) 光吸收不足和低单片氧量子产量 (Φ¹O₂).
目前LW PDT所需的高激光功率密度导致光热辐射,引起疼痛并降低患者的服从性,阻碍临床应用.

研究的目的:

开发新的,可激活的LW光敏化剂 (PSs),增强光吸收和单点氧生成,以提高PDT的疗效.
创建一个可追溯的PDT系统,使用双模态成像来精确地根除瘤,并减少副作用.

主要方法:

通过激子动态剖析策略设计和合成了一系列可pH激活的基LWPSs (LET-R).
使用瞬态光谱学和理论计算,描述了光物理性质,包括光吸收, Φ1O2,系统间交叉和光发射.
开发了一种用叶酸 (FA) 修改的探头 (LET-I-FA),用于定向输送和双模体光和光声成像引导的PDT.

主要成果:

与绿色氨酸相比,激活的LET-I PS在808nm显示出强烈的吸收和3.2倍增强的Φ1O2.
LET-I展示了促进的系统间交叉和增强的LW光发射,通过光谱分析和理论计算得到证实.
在超低的808nm激光功率密度 (0.2W/cm2) 下,LET-I-FA能够在双模成像指导下,完全消除瘤,而不依赖光热协同作用.

结论:

开发的基于pH可激活的氨酸的LW PSs为克服传统PDT的局限性提供了一个有希望的战略.
新的激素动力学剖析方法有效地选可激活的LW PSs,以便可追踪和有效地根除瘤.
这项研究为先进的,患者友好的LW PDT铺平了道路,具有增强的成像能力.

关键词:

激发动力学剖析的动力学长波长光敏化剂的光敏化剂分子成像分子成像技术在pH值上可激活.光动力学疗法是一种光动力学疗法.

更多相关视频

Time-resolved Photophysical Characterization of Triplet-harvesting Organic Compounds at an Oxygen-free Environment Using an iCCD Camera

Time-resolved Photophysical Characterization of Triplet-harvesting Organic Compounds at an Oxygen-free Environment Using an iCCD Camera

Published on: December 27, 2018

An In-House-Built and Light-Emitting-Diode-Based Photodynamic Therapy Device for Enhancing Verteporfin Cytotoxicity in a 2D Cell Culture Model

An In-House-Built and Light-Emitting-Diode-Based Photodynamic Therapy Device for Enhancing Verteporfin Cytotoxicity in a 2D Cell Culture Model

Published on: January 13, 2023

相关概念视频

Photoluminescence: Fluorescence and Phosphorescence

Photoluminescence: Fluorescence and Phosphorescence

Photoluminescence is a process where a molecule absorbs light energy and re-emits it in the form of light. This phenomenon occurs when a substance absorbs photons, promoting its electrons to higher energy level excited states, followed by a relaxation process in which the electrons return to their original ground state energy levels and emit light. Photoluminescence is widely observed in various materials, including semiconductors, and organic and inorganic compounds.
A pair of electrons in a...

Variables Affecting Phosphorescence and Fluorescence

Variables Affecting Phosphorescence and Fluorescence

Fluorescence and phosphorescence are essential phenomena in fields like analytical chemistry, biological imaging, and materials science, where they detect molecular properties and visualize cellular structures. Understanding the variables that influence these luminescent behaviors is crucial for maximizing accuracy and efficiency in their applications. These variables can broadly be grouped into chemical structure, solvent properties, and external conditions, each playing a distinct role in...

Photoreceptors and Visual Pathways

Photoreceptors and Visual Pathways

At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category,...