感染性结核病患者的密切接触者的监测:一个前性队列研究
Zichun Ma1, Shujuan Duan1, Wei Wang1
1Department of Bacteriology and Immunology, Beijing Chest Hospital, Beijing Tuberculosis and Thoracic Tumor Research Institute, Capital Medical University, Postal No 9, Beiguan Street, Tongzhou District, Beijing, 101149, People's Republic of China.
在密切接触者中,结核病 (TB) 感染通常会在24周内发展. 高龄,并发症和BCG痕存在影响结核病感染风险,BCG痕显示有保护作用.
科学领域:
- 传染性疾病 传染性疾病
- 流行病学 流行病学
- 免疫学 免疫学 免疫学
背景情况:
- 监测密切接触者对于有效的结核病查策略至关重要.
- 了解家庭接触者中的结核病感染动态至关重要.
- 干扰素γ释放试验 (IGRA) 是结核病感染评估的一个关键工具.
研究的目的:
- 评估家庭接触者结核病 (TB) 感染的进展情况.
- 用IGRA来确定结核病感染发展的时间表.
- 识别与密切接触者结核病感染相关的风险因素.
主要方法:
- 一项为期12个月的纵向研究,涉及结核病患者的家庭接触者.
- 使用IGRA查结核病感染.
- 分析风险因素,包括年龄,并发症,BCG痕和细菌负载.
主要成果:
- 47.3%的家庭接触者患有结核病感染,大多数人在24周内呈IGRA阳性.
- 高龄和并发性疾病与增加结核病感染风险有关.
- BCG痕存在与较低的IGRA阳性率有关,这表明它具有保护作用.
结论:
- IGRA转化通常发生在暴露后24周内,这表明从亚临床结核病传播.
- 在密切接触者中,BCG痕是对结核病感染的独立保护因素.
- 建议在24周进行重复的IGRA测试,以识别接触者中的感染者.
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