生活方式因素如何改变遗传倾向与肥胖相关现象之间的关联? 使用英国生物银行进行的四向分解分析
Mengrong Zhang1, Joey Ward1, Rona J Strawbridge1,2
1School of Health and Wellbeing, University of Glasgow, Clarice Pears Building, 90 Byers Road, Glasgow, G12 8TB, UK.
BMC medicine
|June 9, 2024
概括
生活方式显著影响了对肥胖的遗传倾向,通过效果修改解释了超过40%的相关性. 这凸显了饮食和运动如何改变肥胖和中心肥胖的遗传风险.
科学领域:
- 遗传学和公共卫生
- 代谢性疾病研究研究
背景情况:
- 肥胖和中心肥胖是复杂的疾病,受到遗传和非遗传因素的影响.
- 遗传倾向和生活方式在发展肥胖的相互作用仍然不完全理解.
研究的目的:
- 研究生活方式因素如何修改或调解肥胖和中心肥胖的遗传风险得分之间的关系.
- 量化生活方式在多大程度上解释了遗传倾向和表型肥胖之间的联系.
主要方法:
- 来自英国生物银行的201,466名欧洲参与者的横截面研究.
- 使用多基因风险评分 (PRS) 来确定体质指数 (BMI-PRS) 和腰部比 (WHR-PRS) 的暴露.
- 评估生活方式因素,包括饮食质量,体力活动,能量摄入,睡眠,吸烟和酒精消费,以了解相互作用和调解效应.
主要成果:
- 生活方式因素解释了42.8%的遗传倾向与肥胖之间的关联,主要是通过效果修改 (41.9%).
- 在中心肥胖症中,生活方式解释了女性的42.1%和男性的69.6%,修改发挥了比调解更大的作用.
- 与女性相比,男性的中心肥胖症中,生活方式和调解解释的相关性比例较高.
结论:
- 生活方式在对肥胖和中心肥胖的遗传倾向的表现中起着重要作用.
- 通过生活方式修改效应是将遗传风险与观察到的肥胖症联系起来的关键机制.
- 建议进行进一步的纵向研究,以确定生活方式和肥胖结果之间的因果关系.
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