介质干细胞疗法治疗耐火复杂的克罗恩周围囊:一个案例系列
A J M Pronk1, K J Beek2, M E Wildenberg3
1Department of Surgery, Amsterdam UMC, location VUMC, De Boelelaan 1117, 1081HV, Amsterdam, The Netherlands. a.pronk@amsterdamumc.nl.
Stem cell research & therapy
|June 9, 2024
概括
介质干细胞治疗 (MST) 对克罗恩周囊有希望,达到40%以上的放射性缓解和70%的临床关闭. 放射性缓解的患者没有复发,这表明MST的潜在疗效.
科学领域:
- 胃肠病学 胃肠病学
- 再生医学是一种再生医学.
- 医疗成像医学成像
背景情况:
- 克罗恩的近囊是一种具有挑战性的并发症.
- 介质干细胞治疗 (MST) 是一种新兴的治疗方法.
- 使用MAGNIFI-CD评分进行放射性评估对于预测治疗成功至关重要.
研究的目的:
- 为了评估MST对复杂克罗恩周囊的有效性.
- 为了将MRI发现 (MAGNIFI-CD得分) 与治疗结果相关联.
- 评估MST后的放射和临床缓解率.
主要方法:
- 该研究包括患有复杂的克罗恩周围囊,耐抗TNF和手术的患者.
- 施用MST是为了手术关闭内部状的开口.
- 主要终点:放射性缓解被定义为在MRI上MAGNIFI-CD得分≤6.
主要成果:
- 43.3%的患者在5个月的中位数后实现了放射性缓解 (MAGNIFI-CD ≤6).
- 中位数MAGNIFI-CD得分显著下降,从15.0降至8.0 (p=0.001).
- 70%的患者实现了临床关闭,在放射性缓解患者中没有复发.
结论:
- MST是一种对耐火性克罗恩周囊的有前途的治疗方法.
- 取得显著的放射学和临床缓解率.
- 放射性缓解似乎预测了长期的成功,并防止复发.
相关概念视频
01:19Mesenchymal Stem Cells
4.7K
Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
4.7K
01:21Inflammatory Bowel Disease V: Surgical Management
139
Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
Here are some common surgical interventions for IBD:
139